Skip to main content

An Overview of Cholesterol Homeostasis

  • Protocol
  • First Online:

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1583))

Abstract

Cholesterol has long been implicated in diverse aspects of human health and disease. As this lipid is both vital and lethal, ensuring that its levels are kept in check is important for maintaining health. However, studying cholesterol homeostasis can be challenging due to the extreme hydrophobic nature of cholesterol and the membranous world it inhabits. This volume of Methods in Molecular Biology brings together 21 techniques covering the gamut of cholesterol homeostasis.

This is a preview of subscription content, log in via an institution.

Buying options

Protocol
USD   49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Springer Nature is developing a new tool to find and evaluate Protocols. Learn more

References

  1. Brown MS, Goldstein JL (1985) A receptor-mediated pathway for cholesterol homeostasis. Nobel Lectures:284–324

    Google Scholar 

  2. Howe V, Sharpe LJ, Alexopoulos SJ, Kunze SV, Chua NK, Li D, Brown AJ (2016) Cholesterol homeostasis: how do cells sense sterol excess? Chem Phys Lipids 199:170–178

    Article  CAS  PubMed  Google Scholar 

  3. Du X, Brown AJ, Yang H (2015) Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites. Curr Opin Lipidol 35:37–42

    Article  CAS  Google Scholar 

  4. Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL, Song BL (2015) Cholesterol transport through lysosome-peroxisome membrane contacts. Cell 161(2):291–306

    Article  CAS  PubMed  Google Scholar 

  5. Brown AJ, Sharpe LJ (2015) Cholesterol synthesis. In: Biochemistry of lipids, lipoproteins, and membranes, 6th edn. Elsevier, The Netherlands.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andrew J. Brown Ph.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media LLC

About this protocol

Cite this protocol

Gelissen, I.C., Brown, A.J. (2017). An Overview of Cholesterol Homeostasis. In: Gelissen, I., Brown, A. (eds) Cholesterol Homeostasis. Methods in Molecular Biology, vol 1583. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6875-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-6875-6_1

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6873-2

  • Online ISBN: 978-1-4939-6875-6

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics