Abstract
The discovery of antibodies that bind to targets with high affinity is now a routine exercise. However, it is still challenging to screen for candidates that, in addition to having excellent biological properties, also have optimal biophysical characteristics. Here, we describe a simple HPLC-based screening method to assess for developability factors earlier in the discovery process.
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Kohli, N., Geddie, M.L. (2017). Novel HPLC-Based Screening Method to Assess Developability of Antibody-Like Molecules. In: Tiller, T. (eds) Synthetic Antibodies. Methods in Molecular Biology, vol 1575. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6857-2_11
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DOI: https://doi.org/10.1007/978-1-4939-6857-2_11
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