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Histamine Receptors as Drug Targets pp 309–352Cite as

Histamine and the Kidney: In Vivo Animal Models

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Abstract

Animal models have been, and for the foreseeable future, will remain pivotal to bridge the gap between the test tube and the human condition. In particular, the use of an animal model provides the unique chance to study the onset and the progression of renal disease, approaching it simultaneously at the functional, morphological, and biochemical levels. Thereby, in vivo models offer the ideal opportunity to develop effective therapy for the optimal management of renal diseases. More specifically, the evaluation of renal functional and morphological parameters can be used to investigate the role of histamine and its receptors in renal (patho)-physiology and to validate histamine receptors as new pharmacological targets in renal diseases. Within this chapter a suitable in vivo model to study diabetic nephropathy and some of the most important parameters to monitor the functional and morphological integrity of the kidney are described.

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Authors and Affiliations

  1. Department of Experimental and Clinical Medicine, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy

    Alessandro Pini

  2. Dipartimento di Scienza e Tecnologiadel Farmaco, University of Turin, Via P. Giuria 9, 10125, Turin, Italy

    Eleonora Veglia & Arianna Carolina Rosa

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  1. Alessandro Pini
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  2. Eleonora Veglia
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  3. Arianna Carolina Rosa
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Correspondence to Alessandro Pini .

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  1. Department of Pharmacology Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Ekaterini Tiligada

  2. Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom

    Madeleine Ennis

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Pini, A., Veglia, E., Rosa, A.C. (2017). Histamine and the Kidney: In Vivo Animal Models. In: Tiligada, E., Ennis, M. (eds) Histamine Receptors as Drug Targets. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6843-5_11

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