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Protein Bioinformatics pp 321–332Cite as

Bioinformatics Analysis of PTM-Modified Protein Interaction Networks and Complexes

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1558))

Abstract

Normal cellular functioning is maintained by macromolecular machines that control both core and specialized molecular tasks. These machines are in large part multi-subunit protein complexes that undergo regulation at multiple levels, from expression of requisite components to a vast array of post-translational modifications (PTMs). PTMs such as phosphorylation, ubiquitination, and acetylation currently number more than 200,000 in the human proteome and function within all molecular pathways. Here we provide a framework for systematically studying these PTMs in the context of global protein–protein interaction networks. This analytical framework allows insight into which functions specific PTMs tend to cluster in, and furthermore which complexes either single or multiple PTM signaling pathways converge on.

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Author information

Authors and Affiliations

  1. Otto-Warburg Laboratory, Max-Planck Institute for Molecular Genetics (MPIMG), Ihnestrasse 63-73, Berlin, Germany

    Jonathan Woodsmith & Ulrich Stelzl

  2. Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Universitätsplatz 1, Graz, Austria

    Ulrich Stelzl

  3. Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA

    Arunachalam Vinayagam

Authors
  1. Jonathan Woodsmith
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  2. Ulrich Stelzl
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  3. Arunachalam Vinayagam
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Corresponding author

Correspondence to Ulrich Stelzl .

Editor information

Editors and Affiliations

  1. Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, USA

    Cathy H. Wu

  2. Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, USA

    Cecilia N. Arighi

  3. Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, District of Columbia, USA

    Karen E. Ross

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Woodsmith, J., Stelzl, U., Vinayagam, A. (2017). Bioinformatics Analysis of PTM-Modified Protein Interaction Networks and Complexes. In: Wu, C., Arighi, C., Ross, K. (eds) Protein Bioinformatics. Methods in Molecular Biology, vol 1558. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6783-4_15

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  • DOI: https://doi.org/10.1007/978-1-4939-6783-4_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6781-0

  • Online ISBN: 978-1-4939-6783-4

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