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Adult Stem Cells pp 293–304Cite as

Optimal Environmental Stiffness for Stem Cell Mediated Ischemic Myocardium Repair

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1553))

Abstract

Cardiovascular diseases related to myocardial infarction (MI) contribute significantly to morbidity and mortality worldwide. The loss of cardiomyocytes during MI is a key factor in the impairment of cardiac-pump functions. Employing cell transplantation has shown great potential as a therapeutic approach in regenerating ischemic myocardium. Several studies have suggested that the therapeutic effects of stem cells vary based on the timing of cell administration. It has been clearly established that the myocardium post-infarction experiences a time-dependent stiffness change, and many studies have highlighted the importance of stiffness (elasticity) of microenvironment on modulating the fate and function of stem cells. Therefore, this chapter outlines our studies and other experiments designed to establish the optimal stiffness of microenvironment that maximizes benefits for maintaining cell survival, promoting phenotypic plasticity, and improving functional specification of the engrafted stem cells.

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Acknowledgments

This work was supported by the National Institutes of Health grants HL105176 and HL114654 (M. Xu).

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH, 45267, USA

    Honghai Liu, Christian Paul & Meifeng Xu

Authors
  1. Honghai Liu
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  2. Christian Paul
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  3. Meifeng Xu
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Corresponding author

Correspondence to Meifeng Xu .

Editor information

Editors and Affiliations

  1. Center for Regenerative Medicine, Università di Roma Tor Vergata, Rome, Italy

    Paolo Di Nardo

  2. Institute of Cardiovascular Sciences St-Boniface Hospital Albrechtsen Research Centre Regenerative Medicine Program College of Medicine Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Sanjiv Dhingra

  3. Division of Metabolic and Cardiovascular Sciences Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA

    Dinender K. Singla

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Liu, H., Paul, C., Xu, M. (2017). Optimal Environmental Stiffness for Stem Cell Mediated Ischemic Myocardium Repair. In: Di Nardo, P., Dhingra, S., Singla, D. (eds) Adult Stem Cells. Methods in Molecular Biology, vol 1553. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6756-8_23

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  • DOI: https://doi.org/10.1007/978-1-4939-6756-8_23

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  • Publisher Name: Humana Press, New York, NY

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