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Genetics of Human Handedness and Laterality

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Lateralized Brain Functions

Part of the book series: Neuromethods ((NM,volume 122))

Abstract

Handedness is the most evident lateralized trait in humans. A weak (~25 %) genetic component has been consistently reported for hand preference across independent studies. Genomic technologies have made rapid progress in increasing throughput and resolution of genetic mapping but their success is largely dependent on the availability of large sample sizes. Hand preference in humans is easily determined and available for tens of thousands of individuals for which genomic data are also available. Yet, strong genetic candidates for hand preference have not been proposed yet. Genetics analyses using quantitative measures of handedness have demonstrated that genes involved in establishing left/right structural laterality play a role in controlling behavioral laterality. Therefore it is crucial how handedness is measured and it is clear that other genetic determinants remain to be discovered. The combination of detailed phenotypes with high throughput technologies promises to advance, in the near future, our understanding of handedness genetics and, in turn, the relevant biology. These discoveries will contribute to addressing one of the long-standing questions in laterality research: what makes some people left-handed?

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References

  1. Berker EA, Berker AH, Smith A (1986) Translation of Broca’s 1865 report. Localization of speech in the third left frontal convolution. Arch Neurol 43(10):1065–1072

    Article  CAS  PubMed  Google Scholar 

  2. Ghirlanda S, Vallortigara G (2004) The evolution of brain lateralization: a game-theoretical analysis of population structure. Proc Biol Sci 271(1541):853–857

    Article  PubMed  PubMed Central  Google Scholar 

  3. Knecht S, Drager B, Deppe M, Bobe L, Lohmann H, Floel A, Ringelstein EB, Henningsen H (2000) Handedness and hemispheric language dominance in healthy humans. Brain 123(Pt 12):2512–2518

    Article  PubMed  Google Scholar 

  4. Bishop DV (2013) Cerebral asymmetry and language development: cause, correlate, or consequence? Science 340(6138):1230531

    Article  PubMed  PubMed Central  Google Scholar 

  5. Brandler WM, Paracchini S (2014) The genetic relationship between handedness and neurodevelopmental disorders. Trends Mol Med 20(2):83–90

    Article  PubMed  PubMed Central  Google Scholar 

  6. Hepper PG (2013) The developmental origins of laterality: fetal handedness. Dev Psychobiol 55(6):588–595

    Article  PubMed  Google Scholar 

  7. Carter-Saltzman L (1980) Biological and sociocultural effects on handedness: comparison between biological and adoptive families. Science 209(4462):1263–1265

    Article  CAS  PubMed  Google Scholar 

  8. Bishop DV (2015) The interface between genetics and psychology: lessons from developmental dyslexia. Proc Biol Sci 282(1806):20143139

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Medland SE, Duffy DL, Wright MJ, Geffen GM, Hay DA, Levy F, van-Beijsterveldt CE, Willemsen G, Townsend GC, White V, Hewitt AW, Mackey DA, Bailey JM, Slutske WS, Nyholt DR, Treloar SA, Martin NG, Boomsma DI (2009) Genetic influences on handedness: data from 25,732 Australian and Dutch twin families. Neuropsychologia 47(2):330–337

    Article  PubMed  Google Scholar 

  10. Macgregor S, Cornes BK, Martin NG, Visscher PM (2006) Bias, precision and heritability of self-reported and clinically measured height in Australian twins. Hum Genet 120(4):571–580

    Article  PubMed  Google Scholar 

  11. Bisazza A, Facchin L, Vallortigara G (2000) Heritability of lateralization in fish: concordance of right-left asymmetry between parents and offspring. Neuropsychologia 38(7):907–912

    Article  CAS  PubMed  Google Scholar 

  12. Annett M (2002) Non-right-handedness and schizophrenia. Br J Psychiatry 181:349–350

    Article  CAS  PubMed  Google Scholar 

  13. McManus IC (1985) Handedness, language dominance and aphasia: a genetic model. Psychol Med Monogr Suppl 8:1–40

    Article  CAS  PubMed  Google Scholar 

  14. Fisher SE, Vargha-Khadem F, Watkins KE, Monaco AP, Pembrey ME (1998) Localisation of a gene implicated in a severe speech and language disorder. Nat Genet 18(2):168–170

    Article  CAS  PubMed  Google Scholar 

  15. Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP (2001) A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 413(6855):519–523

    Article  CAS  PubMed  Google Scholar 

  16. Newbury DF, Monaco AP, Paracchini S (2014) Reading and language disorders: the importance of both quantity and quality. Genes (Basel) 5(2):285–309

    Article  Google Scholar 

  17. Newbury DF, Winchester L, Addis L, Paracchini S, Buckingham LL, Clark A, Cohen W, Cowie H, Dworzynski K, Everitt A, Goodyer IM, Hennessy E, Kindley AD, Miller LL, Nasir J, O'Hare A, Shaw D, Simkin Z, Simonoff E, Slonims V, Watson J, Ragoussis J, Fisher SE, Seckl JR, Helms PJ, Bolton PF, Pickles A, Conti-Ramsden G, Baird G, Bishop DV, Monaco AP (2009) CMIP and ATP2C2 modulate phonological short-term memory in language impairment. Am J Hum Genet 85(2):264–272

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Vernes SC, Newbury DF, Abrahams BS, Winchester L, Nicod J, Groszer M, Alarcon M, Oliver PL, Davies KE, Geschwind DH, Monaco AP, Fisher SE (2008) A functional genetic link between distinct developmental language disorders. N Engl J Med 359(22):2337–2345

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Van Agtmael T, Forrest SM, Del-Favero J, Van Broeckhoven C, Williamson R (2003) Parametric and nonparametric genome scan analyses for human handedness. Eur J Hum Genet 11(10):779–783

    Article  PubMed  Google Scholar 

  20. Warren DM, Stern M, Duggirala R, Dyer TD, Almasy L (2006) Heritability and linkage analysis of hand, foot, and eye preference in Mexican Americans. Laterality 11(6):508–524

    Article  PubMed  Google Scholar 

  21. Somers M, Ophoff RA, Aukes MF, Cantor RM, Boks MP, Dauwan M, de Visser KL, Kahn RS, Sommer IE (2015) Linkage analysis in a Dutch population isolate shows no major gene for left-handedness or atypical language lateralization. J Neurosci 35(23):8730–8736

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Van Agtmael T, Forrest SM, Williamson R (2002) Parametric and non-parametric linkage analysis of several candidate regions for genes for human handedness. Eur J Hum Genet 10(10):623–630

    Article  PubMed  Google Scholar 

  23. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261(5123):921–923

    Article  CAS  PubMed  Google Scholar 

  24. Bloss CS, Delis DC, Salmon DP, Bondi MW (2010) APOE genotype is associated with left-handedness and visuospatial skills in children. Neurobiol Aging 31(5):787–795

    Article  CAS  PubMed  Google Scholar 

  25. Piper BJ, Yasen AL, Taylor AE, Ruiz JR, Gaynor JW, Dayger CA, Gonzalez-Gross M, Kwon OD, Nilsson LG, Day IN, Raber J, Miller JK (2013) Non-replication of an association of Apolipoprotein E2 with sinistrality. Laterality 18(2):251–261

    Article  PubMed  Google Scholar 

  26. Hubacek JA, Piper BJ, Pikhart H, Peasey A, Kubinova R, Bobak M (2013) Lack of an association between left-handedness and APOE polymorphism in a large sample of adults: results of the Czech HAPIEE study. Laterality 18(5):513–519

    Article  PubMed  Google Scholar 

  27. Francks C, Fisher SE, MacPhie IL, Richardson AJ, Marlow AJ, Stein JF, Monaco AP (2002) A genomewide linkage screen for relative hand skill in sibling pairs. Am J Hum Genet 70(3):800–805

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Laval SH, Dann JC, Butler RJ, Loftus J, Rue J, Leask SJ, Bass N, Comazzi M, Vita A, Nanko S, Shaw S, Peterson P, Shields G, Smith AB, Stewart J, DeLisi LE, Crow TJ (1998) Evidence for linkage to psychosis and cerebral asymmetry (relative hand skill) on the X chromosome. Am J Med Genet 81(5):420–427

    Article  CAS  PubMed  Google Scholar 

  29. Medland SE, Duffy DL, Spurdle AB, Wright MJ, Geffen GM, Montgomery GW, Martin NG (2005) Opposite effects of androgen receptor CAG repeat length on increased risk of left-handedness in males and females. Behav Genet 35(6):735–744

    Article  PubMed  Google Scholar 

  30. Hampson E, Sankar JS (2012) Hand preference in humans is associated with testosterone levels and androgen receptor gene polymorphism. Neuropsychologia 50(8):2018–2025

    Article  PubMed  Google Scholar 

  31. Welter D, MacArthur J, Morales J, Burdett T, Hall P, Junkins H, Klemm A, Flicek P, Manolio T, Hindorff L, Parkinson H (2014) The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res 42(database issue):D1001–D1006

    Article  CAS  PubMed  Google Scholar 

  32. Clarke GM, Anderson CA, Pettersson FH, Cardon LR, Morris AP, Zondervan KT (2011) Basic statistical analysis in genetic case-control studies. Nat Protoc 6(2):121–133

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Eriksson N, Macpherson JM, Tung JY, Hon LS, Naughton B, Saxonov S, Avey L, Wojcicki A, Pe'er I, Mountain J (2010) Web-based, participant-driven studies yield novel genetic associations for common traits. PLoS Genet 6(6):e1000993

    Article  PubMed  PubMed Central  Google Scholar 

  34. Armour JA, Davison A, McManus IC (2014) Genome-wide association study of handedness excludes simple genetic models. Heredity 112(3):221–225

    Article  CAS  PubMed  Google Scholar 

  35. McManus IC, Davison A, Armour JA (2013) Multilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies. Ann N Y Acad Sci 1288:48–58

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9(1):97–113

    Article  CAS  PubMed  Google Scholar 

  37. Crovitz HF, Zener K (1962) A group-test for assessing hand- and eye-dominance. Am J Psychol 75:271–276

    Article  CAS  PubMed  Google Scholar 

  38. Annett M (1985) Left, right, hand and brain: the right shift theory. Psychology Press, London

    Google Scholar 

  39. Brandler WM, Morris AP, Evans DM, Scerri TS, Kemp JP, Timpson NJ, Pourcain BS, Smith GD, Ring SM, Stein J, Monaco AP, Talcott JB, Fisher SE, Webber C, Paracchini S (2013) Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. PLoS Genet 9(9):e1003751

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Lien YJ, Chen WJ, Hsiao PC, Tsuang HC (2015) Estimation of heritability for varied indexes of handedness. Laterality 20:469–482

    Article  PubMed  Google Scholar 

  41. Francks C, Fisher SE, Marlow AJ, MacPhie IL, Taylor KE, Richardson AJ, Stein JF, Monaco AP (2003) Familial and genetic effects on motor coordination, laterality, and reading-related cognition. Am J Psychiatry 160(11):1970–1977

    Article  PubMed  Google Scholar 

  42. Francks C, Maegawa S, Lauren J, Abrahams BS, Velayos-Baeza A, Medland SE, Colella S, Groszer M, McAuley EZ, Caffrey TM, Timmusk T, Pruunsild P, Koppel I, Lind PA, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson AJ, Riley BP, Martin NG, Strittmatter SM, Moller HJ, Rujescu D, Clair DS, Muglia P, Roos JL, Fisher SE, Wade-Martins R, Rouleau GA, Stein JF, Karayiorgou M, Geschwind DH, Ragoussis J, Kendler KS, Airaksinen MS, Oshimura M, DeLisi LE, Monaco AP (2007) LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry 12(12):1129–1139, 1057

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Ludwig KU, Mattheisen M, Muhleisen TW, Roeske D, Schmal C, Breuer R, Schulte-Korne G, Muller-Myhsok B, Nothen MM, Hoffmann P, Rietschel M, Cichon S (2009) Supporting evidence for LRRTM1 imprinting effects in schizophrenia. Mol Psychiatry 14(8):743–745

    Article  CAS  PubMed  Google Scholar 

  44. McManus C, Nicholls M, Vallortigara G (2009) Editorial commentary: is LRRTM1 the gene for handedness? Laterality 14(1):1–2

    Article  PubMed  Google Scholar 

  45. Savitz J, van der Merwe L, Solms M, Ramesar R (2007) Lateralization of hand skill in bipolar affective disorder. Genes Brain Behav 6(8):698–705

    Article  CAS  PubMed  Google Scholar 

  46. Scerri TS, Brandler WM, Paracchini S, Morris AP, Ring SM, Richardson AJ, Talcott JB, Stein J, Monaco AP (2011) PCSK6 is associated with handedness in individuals with dyslexia. Hum Mol Genet 20(3):608–614

    Article  CAS  PubMed  Google Scholar 

  47. Arning L, Ocklenburg S, Schulz S, Ness V, Gerding WM, Hengstler JG, Falkenstein M, Epplen JT, Gunturkun O, Beste C (2013) VNTR polymorphism is associated with degree of handedness but not direction of handedness. PLoS One 8(6):e67251

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Hirokawa N, Tanaka Y, Okada Y, Takeda S (2006) Nodal flow and the generation of left-right asymmetry. Cell 125(1):33–45

    Article  CAS  PubMed  Google Scholar 

  49. Grande C, Patel NH (2009) Nodal signalling is involved in left-right asymmetry in snails. Nature 457(7232):1007–1011

    Article  CAS  PubMed  Google Scholar 

  50. Barth KA, Miklosi A, Watkins J, Bianco IH, Wilson SW, Andrew RJ (2005) fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses. Curr Biol 15(9):844–850

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Mooney MA, Nigg JT, McWeeney SK, Wilmot B (2014) Functional and genomic context in pathway analysis of GWAS data. Trends Genet 30(9):390–400

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Ng A, Wong M, Viviano B, Erlich JM, Alba G, Pflederer C, Jay PY, Saunders S (2009) Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Dev Biol 335(1):208–215

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Zhou J, Yang F, Leu NA, Wang PJ (2012) MNS1 is essential for spermiogenesis and motile ciliary functions in mice. PLoS Genet 8(3):e1002516

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Bonnafe E, Touka M, AitLounis A, Baas D, Barras E, Ucla C, Moreau A, Flamant F, Dubruille R, Couble P, Collignon J, Durand B, Reith W (2004) The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol Cell Biol 24(10):4417–4427

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Pennekamp P, Karcher C, Fischer A, Schweickert A, Skryabin B, Horst J, Blum M, Dworniczak B (2002) The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol 12(11):938–943

    Article  CAS  PubMed  Google Scholar 

  56. Benadiba C, Magnani D, Niquille M, Morle L, Valloton D, Nawabi H, Ait-Lounis A, Otsmane B, Reith W, Theil T, Hornung JP, Lebrand C, Durand B (2012) The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development. PLoS Genet 8(3):e1002606

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. McManus IC, Martin N, Stubbings GF, Chung EM, Mitchison HM (2004) Handedness and situs inversus in primary ciliary dyskinesia. Proc Biol Sci 271(1557):2579–2582

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Sun T, Walsh CA (2006) Molecular approaches to brain asymmetry and handedness. Nat Rev Neurosci 7(8):655–662

    Article  CAS  PubMed  Google Scholar 

  59. Deciphering Developmental Disorders S (2015) Large-scale discovery of novel genetic causes of developmental disorders. Nature 519(7542):223–228

    Google Scholar 

  60. Wang K, Li M, Hakonarson H (2010) ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 38(16):e164

    Article  PubMed  PubMed Central  Google Scholar 

  61. Kavaklioglu T, Ajmal M, Hameed A, Francks C (2015) Whole exome sequencing for handedness in a large and highly consanguineous family., Neuropsychologia

    Google Scholar 

  62. Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ (2010) Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet 6(4):e1000888

    Article  PubMed  PubMed Central  Google Scholar 

  63. Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M (2012) An integrated encyclopedia of DNA elements in the human genome. Nature 489(7414):57–74

    Article  Google Scholar 

  64. Dennis MY, Paracchini S, Scerri TS, Prokunina-Olsson L, Knight JC, Wade-Martins R, Coggill P, Beck S, Green ED, Monaco AP (2009) A common variant associated with dyslexia reduces expression of the KIAA0319 gene. PLoS Genet 5(3):e1000436

    Article  PubMed  PubMed Central  Google Scholar 

  65. Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, Sousa AM, Pletikos M, Meyer KA, Sedmak G, Guennel T, Shin Y, Johnson MB, Krsnik Z, Mayer S, Fertuzinhos S, Umlauf S, Lisgo SN, Vortmeyer A, Weinberger DR, Mane S, Hyde TM, Huttner A, Reimers M, Kleinman JE, Sestan N (2011) Spatio-temporal transcriptome of the human brain. Nature 478(7370):483–489

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Shore R, Covill L, Pettigrew KA, Brandler WM, Diaz R, Xu Y, Tello J, Talcott J, Newbury DF, Stein J, Monaco AP, Paracchini S (2016) The handedness-associated PCSK6 locus spans a bidirectional promoter regulating novel transcripts. Hum Mol Genet 25(9):1771–1779

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Paracchini S, Scerri T, Monaco AP (2007) The genetic lexicon of dyslexia. Annu Rev Genomics Hum Genet 8:57–79

    Article  CAS  PubMed  Google Scholar 

  68. Geschwind DH, Miller BL, DeCarli C, Carmelli D (2002) Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness. Proc Natl Acad Sci U S A 99(5):3176–3181

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, Orkin SH, Geschwind DH, Walsh CA (2005) Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science 308(5729):1794–1798

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Johnson MB, Kawasawa YI, Mason CE, Krsnik Z, Coppola G, Bogdanovic D, Geschwind DH, Mane SM, State MW, Sestan N (2009) Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron 62(4):494–509

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Lambert N, Lambot MA, Bilheu A, Albert V, Englert Y, Libert F, Noel JC, Sotiriou C, Holloway AK, Pollard KS, Detours V, Vanderhaeghen P (2011) Genes expressed in specific areas of the human fetal cerebral cortex display distinct patterns of evolution. PLoS One 6(3):e17753

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Pletikos M, Sousa AM, Sedmak G, Meyer KA, Zhu Y, Cheng F, Li M, Kawasawa YI, Sestan N (2014) Temporal specification and bilaterality of human neocortical topographic gene expression. Neuron 81(2):321–332

    Article  CAS  PubMed  Google Scholar 

  73. Durand CM, Betancur C, Boeckers TM, Bockmann J, Chaste P, Fauchereau F, Nygren G, Rastam M, Gillberg IC, Anckarsater H, Sponheim E, Goubran-Botros H, Delorme R, Chabane N, Mouren-Simeoni MC, de Mas P, Bieth E, Roge B, Heron D, Burglen L, Gillberg C, Leboyer M, Bourgeron T (2007) Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet 39(1):25–27

    Article  CAS  PubMed  Google Scholar 

  74. Waga C, Okamoto N, Ondo Y, Fukumura-Kato R, Goto Y, Kohsaka S, Uchino S (2011) Novel variants of the SHANK3 gene in Japanese autistic patients with severe delayed speech development. Psychiatr Genet 21(4):208–211

    Article  PubMed  Google Scholar 

  75. Meda SA, Gelernter J, Gruen JR, Calhoun VD, Meng H, Cope NA, Pearlson GD (2008) Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals—a preliminary voxel based morphometry study. Brain Imaging Behav 2(1):21–26

    Article  PubMed  PubMed Central  Google Scholar 

  76. Guadalupe T, Zwiers MP, Teumer A, Wittfeld K, Vasquez AA, Hoogman M, Hagoort P, Fernandez G, Buitelaar J, Hegenscheid K, Volzke H, Franke B, Fisher SE, Grabe HJ, Francks C (2014) Measurement and genetics of human subcortical and hippocampal asymmetries in large datasets. Hum Brain Mapp 35(7):3277–3289

    Article  PubMed  Google Scholar 

  77. Leventer RJ, Scerri T, Marsh AP, Pope K, Gillies G, Maixner W, MacGregor D, Harvey AS, Delatycki MB, Amor DJ, Crino P, Bahlo M, Lockhart PJ (2015) Hemispheric cortical dysplasia secondary to a mosaic somatic mutation in MTOR. Neurology 84(20):2029–2032

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Lee JH, Huynh M, Silhavy JL, Kim S, Dixon-Salazar T, Heiberg A, Scott E, Bafna V, Hill KJ, Collazo A, Funari V, Russ C, Gabriel SB, Mathern GW, Gleeson JG (2012) De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. Nat Genet 44(8):941–945

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Paabo S (2014) The human condition—a molecular approach. Cell 157(1):216–226

    Article  PubMed  Google Scholar 

  80. Ayub Q, Yngvadottir B, Chen Y, Xue Y, Hu M, Vernes SC, Fisher SE, Tyler-Smith C (2013) FOXP2 targets show evidence of positive selection in European populations. Am J Hum Genet 92(5):696–706

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Enard W, Gehre S, Hammerschmidt K, Holter SM, Blass T, Somel M, Bruckner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Muller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Holzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, de Angelis MH, Fischer J, Schwarz J, Paabo S (2009) A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 137(5):961–971

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Silvia Paracchini is a Royal Society University Research Fellow. The authors would like to thank Dr. William Brandler for useful comments on the manuscript of this chapter.

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Authors and Affiliations

  1. School of Medicine, University of St Andrews, North Haugh, St. Andrews, KY16 8LG, Scotland

    Silvia Paracchini

  2. Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia

    Tom Scerri

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  1. Silvia Paracchini
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  2. Tom Scerri
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Correspondence to Silvia Paracchini .

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Editors and Affiliations

  1. School of Science and Technology, University of New England, Armidale, Australia

    Lesley J. Rogers

  2. Centre for Mind/Brain Sciences, University of Trento, Trento, Trento, Italy

    Giorgio Vallortigara

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Paracchini, S., Scerri, T. (2017). Genetics of Human Handedness and Laterality. In: Rogers, L., Vallortigara, G. (eds) Lateralized Brain Functions. Neuromethods, vol 122. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6725-4_16

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  • DOI: https://doi.org/10.1007/978-1-4939-6725-4_16

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