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Piloting Your Nanovehicle to Overcome Biological Barriers

  • Steven M. Richards
  • Robert B. Campbell
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1530)

Abstract

Designing an effective nanoparticle for selective drug transport requires careful consideration of the complex biological barriers encountered in transit to the desired target. Here, we review several of these barriers, and provide possible methods for formulating liposomal nanoparticles to overcome them. The methods include the biotinylation of an antibody, and subsequent conjugation to a PEGylated cationic lipid nanoparticle. Additionally, the incorporation of drug, and other relevant characteristics of the nanoparticle are also discussed.

Key words

Nanoparticles Liposomes Barriers Bevacizumab Angiogenesis Drug resistance Drug carriers Drug delivery systems 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Pharmaceutical SciencesMCPHS UniversityWorcesterUSA

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