Fabrication of Photothermal Stable Gold Nanosphere/Mesoporous Silica Hybrid Nanoparticle Responsive to Near-Infrared Light
Various gold nanoparticles have been explored in biomedical systems and proven to be promising in photothermal therapy and drug delivery. Among them, nanoshells were regarded as traditionally strong near infrared absorbers that have been widely used to generate photothermal effect for cancer therapy. However, the nanoshell is not photo-thermal stable and thus is not suitable for repeated irradiation. Here, we describe a novel discrete gold nanostructure by mimicking the continuous gold nanoshell—gold/mesoporous silica hybrid nanoparticle (GoMe). It possesses the best characteristics of both conventional gold nanoparticles and mesoporous silica nanoparticles, such as excellent photothermal converting ability as well as high drug loading capacity and triggerable drug release.
Key wordsGold nanoparticle Mesoporous silica nanoparticle Redox responsive Photothermal therapy
The authors want to thank the ASPIRE award from the Office of the Vice President for Research of The University of South Carolina, the National Cancer Institute (1R15CA188847-01A1 and CCSG P30 CA44579), and the Center for Targeted Therapeutics (1P20GM109091-01) for financial support.
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