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Neutron-Activatable Nanoparticles for Intraperitoneal Radiation Therapy

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Cancer Nanotechnology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1530))

Abstract

Intraperitoneal internal radiation therapy is a cancer treatment option that is employed in situations where surgical resection, systemic chemotherapy, and external beam radiotherapy are not amenable for patients. However, exposure of noncancerous tissues to radiation continues to be a hindrance to safe and effective treatment of patients. In addition, reducing prolonged radiation exposure of personnel during preparation of internal radiation therapy agents makes their manufacture complicated and hazardous. Developments in nanotechnology have provided a platform for targeted treatments that combine dual imaging and treatment capabilities all in one package, while also being robust enough to withstand the intense stresses faced during neutron activation. Here, we describe a method for synthesizing neutron activatable mesoporous silica nanoparticles for use in radiotherapy of metastatic peritoneal cancers while limiting personal exposure to radioactive materials, limiting the leakage of radioactive isotopes caused by nanoparticle degradation during neutron activation, and increasing cancer tissue specificity of radiation.

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Acknowledgments

The work is supported by National Cancer Institute (NCI) R03CA184394 and the Research Scholar Grant, RSG-15-011-01-CDD from the American Cancer Society.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA

    Derek Hargrove & Xiuling Lu

Authors
  1. Derek Hargrove
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  2. Xiuling Lu
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Corresponding author

Correspondence to Xiuling Lu .

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Editors and Affiliations

  1. School of Applied Sciences, Mount Ida College, Newton, Massachusetts, USA

    Reema Zeineldin

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Hargrove, D., Lu, X. (2017). Neutron-Activatable Nanoparticles for Intraperitoneal Radiation Therapy. In: Zeineldin, R. (eds) Cancer Nanotechnology. Methods in Molecular Biology, vol 1530. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6646-2_24

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  • DOI: https://doi.org/10.1007/978-1-4939-6646-2_24

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6644-8

  • Online ISBN: 978-1-4939-6646-2

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