Molecular Network Dynamics of Cell Cycle Control: Periodicity of Start and Finish

  • Alida Palmisano
  • Judit Zámborszky
  • Cihan Oguz
  • Attila Csikász-Nagy
Part of the Methods in Molecular Biology book series (MIMB, volume 1524)


The cell division cycle is controlled by a complex regulatory network which ensures that the phases of the cell cycle are executed in the right order. This regulatory network receives signals from the environment, monitors the state of the DNA, and decides timings of cell cycle events. The underlying transcriptional and post-translational regulatory interactions lead to complex dynamical responses, such as the oscillations in the levels of cell cycle proteins driven by intertwined biochemical reactions. A cell moves between different phases of its cycle similar to a dynamical system switching between its steady states. The complex molecular network driving these phases has been investigated in previous computational systems biology studies. Here, we review the critical physiological and molecular transitions that occur in the cell cycle and discuss the role of mathematical modeling in elucidating these transitions and understand cell cycle synchronization.

Key words

Systems biology Bistability Oscillation Mathematical and computational models Checkpoints Budding yeast Hysteresis Synchronization Periodic forcing 


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Alida Palmisano
    • 1
    • 2
  • Judit Zámborszky
    • 3
  • Cihan Oguz
    • 1
  • Attila Csikász-Nagy
    • 4
    • 5
  1. 1.Department of Biological SciencesVirginia TechBlacksburgUSA
  2. 2.Department of Computer ScienceVirginia TechBlacksburgUSA
  3. 3.Hungarian Academy of Sciences, Research Centre for Natural SciencesInstitute of EnzymologyBudapestHungary
  4. 4.Randall Division of Cell and Molecular Biophysics, Institute for Mathematical and Molecular BiomedicineKing’s College LondonLondonUK
  5. 5.Faculty of Information Technology and BionicsPázmány Péter Catholic UniversityBudapestHungary

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