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Liposomes pp 257–272Cite as

Targeted Magnetic Liposomes Loaded with Doxorubicin

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1522))

Abstract

Targeted delivery systems for anticancer drugs are urgently needed to achieve maximum therapeutic efficacy by site-specific accumulation and thereby minimizing adverse effects resulting from systemic distribution of many potent anticancer drugs. We have prepared folate receptor-targeted magnetic liposomes loaded with doxorubicin, which are designed for tumor targeting through a combination of magnetic and biological targeting. Furthermore, these liposomes are designed for hyperthermia-induced drug release to be mediated by an alternating magnetic field and to be traceable by magnetic resonance imaging (MRI). Here, detailed preparation and relevant characterization techniques of targeted magnetic liposomes encapsulating doxorubicin are described.

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Acknowledgements

Financial support of the German Excellence Initiative via the “Nanosystems Initiative Munich (NIM)” is gratefully acknowledged. Pallab Pradhan gratefully acknowledges DAAD (Deutscher Akademischer Austausch Dienst) for awarding the “DAAD Sandwich fellowship” for pursuing the research in Germany. Support from DST, Govt. of India is also gratefully acknowledged.

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Authors and Affiliations

  1. Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India

    Pallab Pradhan & Rinti Banerjee

  2. Institute of Molecular Immunology & Experimental Oncology, Technische Universität München, Munich, Germany

    Pallab Pradhan, Christian Koch, Olga Mykhaylyk & Christian Plank

  3. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, Atlanta, GA, 30332-0535, USA

    Pallab Pradhan

  4. Department of Metallurgical Engineering and Materials Science, IIT Bombay, Mumbai, India

    Dhirendra Bahadur

Authors
  1. Pallab Pradhan
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  2. Rinti Banerjee
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  3. Dhirendra Bahadur
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  4. Christian Koch
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  5. Olga Mykhaylyk
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  6. Christian Plank
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Corresponding author

Correspondence to Pallab Pradhan .

Editor information

Editors and Affiliations

  1. School of Pharmacy – Boston, MCPHS University, Boston, Massachusetts, USA

    Gerard G.M. D'Souza

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Pradhan, P., Banerjee, R., Bahadur, D., Koch, C., Mykhaylyk, O., Plank, C. (2017). Targeted Magnetic Liposomes Loaded with Doxorubicin. In: D'Souza, G. (eds) Liposomes. Methods in Molecular Biology, vol 1522. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6591-5_21

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  • DOI: https://doi.org/10.1007/978-1-4939-6591-5_21

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6589-2

  • Online ISBN: 978-1-4939-6591-5

  • eBook Packages: Springer Protocols

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