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The Expanding World of Small Molecule Microarrays

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Small Molecule Microarrays

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1518))

Abstract

Speed and throughput are vital ingredients for discovery driven, “-omics” research. The small molecule microarray (SMM) succeeds at delivering phenomenal screening throughput and versatility. The concept at the heart of the technology is elegant, yet simple: by presenting large collections of molecules in high density on a flat surface, one is able to interrogate all possible interactions with desired targets, in just a single step. SMMs have become established as the choice platform for screening, lead discovery, and molecular characterization. This introduction describes the principles governing microarray construction and use, focusing on practical challenges faced when conducting SMM experiments. It will explain the key design considerations and lay the foundation for the chapters that follow. (An earlier version of this chapter appeared in Small Molecule Microarrays: Methods and Protocols, published in 2010.)

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Acknowledgments

We gratefully acknowledge financial support by Singapore National Medical Research Council (CBRG/0038/2013), the Ministry of Education (MOE2013-T2-1-048), and DSO National Laboratories.

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Authors and Affiliations

  1. Defence Medical and Environmental Research Institute, DMERI, DSO National Laboratories, #09-01, 27 Medical Drive, Singapore, Singapore, 117510

    Mahesh Uttamchandani

  2. Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, Singapore, Singapore, 117543

    Mahesh Uttamchandani & Shao Q. Yao

Authors
  1. Mahesh Uttamchandani
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  2. Shao Q. Yao
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Correspondence to Mahesh Uttamchandani or Shao Q. Yao .

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Editors and Affiliations

  1. DSO National Laboratories, Defence Medical and Environmental Resear, Singapore, Singapore

    Mahesh Uttamchandani

  2. Department of Chemistry Faculty of Science, National University of Singapore, Singapore, Singapore

    Shao Q. Yao

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Uttamchandani, M., Yao, S.Q. (2017). The Expanding World of Small Molecule Microarrays. In: Uttamchandani, M., Yao, S. (eds) Small Molecule Microarrays. Methods in Molecular Biology, vol 1518. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6584-7_1

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  • DOI: https://doi.org/10.1007/978-1-4939-6584-7_1

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  • Print ISBN: 978-1-4939-6582-3

  • Online ISBN: 978-1-4939-6584-7

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