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Systemic Antifungal Agents: Current Status and Projected Future Developments

  • Seyedmojtaba SeyedmousaviEmail author
  • Haleh Rafati
  • Macit Ilkit
  • Ali Tolooe
  • Mohammad T. Hedayati
  • Paul Verweij
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1508)

Abstract

By definition, an antifungal agent is a drug that selectively destroys fungal pathogens with minimal side effects to the host. Despite an increase in the prevalence of fungal infections particularly in immunocompromised patients, only a few classes of antifungal drugs are available for therapy, and they exhibit limited efficacy in the treatment of life-threatening infections. These drugs include polyenes, azoles, echinocandins, and nucleoside analogs. This chapter focuses on the currently available classes and representatives of systemic antifungal drugs in clinical use. We further discuss the unmet clinical needs in the antifungal research field; efforts in reformulation of available drugs such as Amphotericin B nanoparticles for oral drug delivery; development of new agents of known antifungal drug classes, such as albaconazole, SCY-078, and biafungin; and new drugs with novel targets for treatment of invasive fungal infections, including nikkomycin Z, sordarin derivatives, VT-1161 and VT-1129, F901318, VL-2397, and T-2307.

Key words

Antifungal agents Systemic fungal infections Amphotericin B nanoparticles Albaconazole SCY-078 Biafungin-Nikkomycin Z Sordarins VT-1161 VT-1129 F901318 VL-2397 T-2307 

Notes

Conflicts of Interest

S.S. received research grant from Astellas Pharma B.V. P.E.V. has served as a consultant and received research grants from Astellas, Basilea, Gilead Sciences, Merck, and Pfizer. All other authors have no conflict of interests.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Seyedmojtaba Seyedmousavi
    • 1
    • 2
    Email author
  • Haleh Rafati
    • 3
  • Macit Ilkit
    • 4
  • Ali Tolooe
    • 5
  • Mohammad T. Hedayati
    • 6
  • Paul Verweij
    • 1
  1. 1.Department of Medical MicrobiologyRadboud University Medical CenterNijmegenThe Netherlands
  2. 2.Invasive Fungi Research Center (IFRC) & Department of Medical Mycology and ParasitologySchool of Medicine, Mazandaran University of Medical SciencesSariIran
  3. 3.Department of BiochemistryErasmus University Medical CenterRotterdamThe Netherlands
  4. 4.Division of Mycology, Department of Microbiology, Faculty of MedicineUniversity of ÇukurovaAdanaTurkey
  5. 5.Department of Medical Mycology and Parasitology, School of Medicine, Invasive Fungi Research Center (IFRC)Mazandaran University of Medical SciencesSariIran
  6. 6.Faculty of Veterinary MedicineUniversity of TehranTehranIran

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