Serological Approaches

  • Barbora WeinbergerovaEmail author
  • Iva Kocmanova
  • Zdenek Racil
  • Jiri Mayer
Part of the Methods in Molecular Biology book series (MIMB, volume 1508)


The diagnosis of invasive fungal diseases (IFD) based on clinical, radiological, and conventional microbiological findings is not reliable and is often delayed. Non-culture-based methods with higher sensitivity and specificity may reduce diagnostic time and result in decreased IFD morbidity and mortality. These methods are now increasingly used to manage patients at risk of IFD. Among available biomarkers, fungal antigens have been investigated as an aid to early diagnosis and are predominantly used as screening tests to prompt antifungal treatment mainly in patients with hematological malignancies. The revised version of the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) consensus definitions includes some of these biological markers (galactomannan, 1,3-beta-d-glucan, cryptococcus antigen).

Key words

Galactomannan The Platelia Aspergillus enzyme immunoassay Latex agglutination Aspergillus lateral-flow device 1,3-beta-d-glucan Fungitell assay 


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Barbora Weinbergerova
    • 1
    Email author
  • Iva Kocmanova
    • 1
    • 2
  • Zdenek Racil
    • 1
    • 3
  • Jiri Mayer
    • 1
    • 3
  1. 1.Department of Internal Medicine—Hematology and OncologyMasaryk University and University Hospital BrnoBrnoCzech Republic
  2. 2.Department of MicrobiologyUniversity Hospital BrnoBrnoCzech Republic
  3. 3.CEITEC—Central European Institute of TechnologyMasaryk UniversityBrnoCzech Republic

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