Abstract
The liver has an important function in the human body and plays a crucial role in its metabolism. Orthotopic liver transplantation (OLT) is the gold standard treatment for patients presenting liver failure or end stage liver diseases, and is also applied for liver based intractable metabolic disorders. Due to organ shortage, invasive surgery and persistent mortality/morbidity, other treatments have to be explored. Amongst these, hepatocyte transplantation is an attractive alternative and has shown promising results in the treatment of miscellaneous metabolic disorders.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Puppi J, Strom SC, Hughes RD et al (2012) Improving the techniques for human hepatocyte transplantation: report form a consensus meeting in London. Cell Transplant 21:1–10
Fox IJ, Roy-Chowdhury J (2004) Hepatocyte transplantation. J Hepatol 40:878–886
Fischer RA, Strom SC (2006) Human hepatocyte transplantation: worldwide results. Transplantation 82:441–449
Smets F, Najimi M, Sokal EM (2008) Cell transplantation in the treatment of liver diseases. Pediatr Transplant 12:6–13
Strom SC, Roy-Chowdhury J, Fox IJ (1999) Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis 19(1):39–48
Najimi M, Sokal E (2005) Liver cell transplantation. Minerva Pediatr 57:243–257
Stéphenne X, Najimi M, Ngoc DK et al (2007) Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain complex. Cell Transplant 16:409–419
Stéphenne X, Najimi M, Sokal EM (2010) Hepatocyte cryopreservation: is it time to change the strategy? World J Gastroenterol 16(1):1–14
Dhawan A, Strom SC, Sokal E, Fox IJ (2010) Human hepatocyte transplantation. Methods Mol Biol 640:525–534
Mitry RR, Dhawan A, Hughes RD et al (2004) One liver, three recipients: segment IV from split-liver procedures as a source of hepatocytes for cell transplantation. Transplantation 77(10):1614–1646
Stéphenne X, Debray FG, Smets F et al (2012) Hepatocyte transplantation using the domino concept in a child with Tetrabiopterin non-responsive pheynylketonuria. Cell Transplant 21:2765–2770
Gramignoli R, Tahan V, Dorko K et al (2013) New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants. Stem Cell Res 11:563–573
Sokal E (2011) From hepatocytes to stem and progenitor cells for liver regenerative medicine: advances and clinical perspectives. Cell Prolif 44(Suppl 1):39–43
Najimi M, Dung NK, Lysy P et al (2007) Adult-derived human liver mesenchymal-like cells as a potential progenitor reservoir of hepatocytes. Cell Transplant 16:717–728
Habibullah CM, Syed IH, Qamar A, Taher-Uz Z (1994) Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 58:951–977
Dan YY, Riehle KJ, Lazaro CI et al (2006) Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages. Proc Natl Acad Sci U S A 103:384–390
Moscioni AD, Roy-Chowdhury J, Barbour R et al (1989) Human liver cell transplantation. Prolonged function in athymic-Gunn and athymic-analbuminemic hybrid rats. Gastroenterology 96:1546–1551
Schneider A, Attaran M, Meier PN et al (2006) Hepatocyte transplantation in an acute liver failure due to mushroom poisoning. Transplantation 82:1115–1116
Stéphenne X, Najimi M, Smets F et al (2005) Cryopreserved liver cell transplantation controls ornithine transcarbamylase deficient patient while awaiting liver transplantation. Am J Transplant 5:2058–2061
Stéphenne X, Najimi M, Sibille C et al (2006) Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency. Gastroenterology 130:1317–1323
Meyburg J, Das AM, Hoerster F et al (2009) One liver for four children: first clinical series of liver cell transplantation for severe neonatal urea cycle defects. Transplantation 87:636–641
Lysy PA, Najimi M, Stéphenne X et al (2008) Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives. World J Gastroenterol 14:3464–3470
Fox IJ, Chowdhury JR, Kaufman SS et al (1998) Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 338:1422–1426
Muraca M, Gerunda G, Neri D et al (2002) Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet 359:317–318
Sokal EM, Smets F, Bourgois A et al (2003) Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up. Transplantation 76:735–738
Sokal EM (2006) Liver transplantation for inborn errors of liver metabolism. J Inherit Metab Dis 29:426–430
Balladur P, Crema A, Honiger J et al (1995) Transplantation of allogeneic hepatocytes without immunosuppression: longterm survival. Surgery 117:189–194
Gramignoli R, Vosough M, Kannisto K et al (2015) Clinical hepatocyte transplantation: practical limits and possible solutions. Eur Surg Res 54:162–177
Darwish A, Sokal EM, Stéphenne X et al (2004) Permanent access to the portal system for cellular transplantation using an implantable port device. Liver Transplant 10:1213–1215
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Science+Business Media New York
About this protocol
Cite this protocol
Coppin, L., Sokal, E., Stephenne, X. (2017). Hepatocyte Transplantation in Children. In: Stock, P., Christ, B. (eds) Hepatocyte Transplantation. Methods in Molecular Biology, vol 1506. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6506-9_21
Download citation
DOI: https://doi.org/10.1007/978-1-4939-6506-9_21
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-6504-5
Online ISBN: 978-1-4939-6506-9
eBook Packages: Springer Protocols