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Hepatocyte Transplantation pp 17–42Cite as

Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1506))

Abstract

Adult hepatocyte transplantation is limited by scarce availability of suitable donor liver tissue for hepatocyte isolation. New cell-based therapies are being developed to supplement whole-organ liver transplantation, to reduce the waiting-list mortality rate, and to obtain more sustained and significant metabolic correction. Fetal livers and unsuitable neonatal livers for organ transplantation have been proposed as potential useful sources of hepatic cells for cell therapy. However, the major challenge is to use alternative cell sources for transplantation that can be derived from reproducible methods. Different types of stem cells with hepatic differentiation potential are eligible for generating large numbers of functional hepatocytes for liver cell therapy to treat degenerative disorders, inborn hepatic metabolic diseases, and organ failure. Clinical trials are designed to fully establish the safety profile of such therapies and to define target patient groups and standardized protocols.

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Authors and Affiliations

  1. Unidad de Cirugıa Hepato-Bilio-Pancreatica y Trasplante Hepatico, Hospital Universitario y Politécnico La Fe de Valencia, Avenida Fernando Abril Martorel 106, 46026, Valencia, Spain

    Eugenia Pareja

  2. Unidad de Terapia Celular Hepática, Instituto de Investigación Sanitaria La Fe, Hospital Universitario y Politécnico La Fe de Valencia, 46026, Valencia, Spain

    Eugenia Pareja, María José Gómez-Lechón & Laia Tolosa

  3. Unidad de Hepatologıa Experimental, Instituto de Investigación Sanitaria La Fe, Hospital Universitario y Politécnico La Fe de Valencia, 46026, Valencia, Spain

    María José Gómez-Lechón & Laia Tolosa

  4. CIBERehd, FIS, Barcelona, 08036, Spain

    María José Gómez-Lechón

Authors
  1. Eugenia Pareja
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  2. María José Gómez-Lechón
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  3. Laia Tolosa
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Corresponding author

Correspondence to Eugenia Pareja .

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Editors and Affiliations

  1. Department of Surgery, University of Leipzig, Leipzig, Germany

    Peggy Stock

  2. Department of Surgery, University of Leipzig, Leipzig, Germany

    Bruno Christ

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Pareja, E., Gómez-Lechón, M.J., Tolosa, L. (2017). Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy. In: Stock, P., Christ, B. (eds) Hepatocyte Transplantation. Methods in Molecular Biology, vol 1506. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6506-9_2

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  • DOI: https://doi.org/10.1007/978-1-4939-6506-9_2

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  • Print ISBN: 978-1-4939-6504-5

  • Online ISBN: 978-1-4939-6506-9

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