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Hepatocyte Transplantation in Special Populations: Clinical Use in Children

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Hepatocyte Transplantation

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1506))

Abstract

Orthotopic liver transplantation remains the only proven cure for end-stage liver failure. Despite significant advances in the field, the clinical demand for donor organs far outweighs the supply. Hepatocyte transplantation has been proposed as an alternative approach to whole liver transplant in select diseases. Several international centers have reported experimental trials of human hepatocyte transplantation in acute liver failure and liver-based metabolic disorders. This chapter provides an introduction to hepatocyte transplantation from both a technical and clinical perspective. We will also focus on the special needs of pediatric patients, since historically the majority of clinical hepatocyte transplants have involved infants and children.

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Acknowledgements

Dr. Khan acknowledges grant support from NIH/NICHD PHS K12HD052892, the Alpha-1 Foundation, and the Hillman Foundation. Dr. Strom acknowledges grant support from Torsten och Ragnar Söderberg Stiftelse (Foundation) and the Center for Innovative Medicine.

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Authors and Affiliations

  1. Department of Pediatric Gastroenterology and Pathology, Children’s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA

    Zahida Khan

  2. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Zahida Khan

  3. Division of Pathology, Department of Laboratory Medicine, Cell Transplantation and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden

    Stephen C. Strom

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  1. Zahida Khan
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  2. Stephen C. Strom
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Correspondence to Zahida Khan .

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Editors and Affiliations

  1. Department of Surgery, University of Leipzig, Leipzig, Germany

    Peggy Stock

  2. Department of Surgery, University of Leipzig, Leipzig, Germany

    Bruno Christ

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Khan, Z., Strom, S.C. (2017). Hepatocyte Transplantation in Special Populations: Clinical Use in Children. In: Stock, P., Christ, B. (eds) Hepatocyte Transplantation. Methods in Molecular Biology, vol 1506. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6506-9_1

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  • DOI: https://doi.org/10.1007/978-1-4939-6506-9_1

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