Abstract
The simplest practical route to producing precisely designed 3D macroscopic objects is to form a crystalline arrangement by self-assembly, because such a periodic array has only conceptually simple requirements: a motif that has a robust 3D structure, dominant affinity interactions between parts of the motif when it self-associates, and predictable structures for these affinity interactions. Fulfilling these three criteria to produce a 3D periodic system is not easy, but should readily be achieved with well-structured branched DNA motifs tailed by sticky ends (Zheng et al., Nature 461:74–77, 2009). Herein, a brief introduction to designed 3D DNA crystals from tensegrity triangle is presented.
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Acknowledgement
This research has been supported by the following grants to NCS: EFRI-1332411, and CCF-1526650 from the NSF, MURI W911NF-11-1-0024 from ARO, MURI N000140911118 from ONR, DE-SC0007991 from DOE for partial salary support, and grant GBMF3849 from the Gordon and Betty Moore Foundation.
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Seeman, N.C. et al. (2017). Designed 3D DNA Crystals. In: Ke, Y., Wang, P. (eds) 3D DNA Nanostructure. Methods in Molecular Biology, vol 1500. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6454-3_1
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DOI: https://doi.org/10.1007/978-1-4939-6454-3_1
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