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Studying the CCN Proteins in Fibrosis

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Book cover CCN Proteins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1489))

Abstract

CCN2 is a profibrotic matricellular protein. CCN2 directly promotes cell adhesion and indirectly promotes fibrosis by activating adhesive signaling in response to growth factors, cytokines, and extracellular matrix. The following protocols will allow the direct assessment of other CCN family members in these processes.

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Author information

Authors and Affiliations

  1. Departments of Dentistry and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Dental Sciences Building, London, ON, Canada, N6A 5C1

    James Hutchenreuther, Andrew Leask & Katherine Thompson

Authors
  1. James Hutchenreuther
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  2. Andrew Leask
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  3. Katherine Thompson
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Corresponding author

Correspondence to Andrew Leask .

Editor information

Editors and Affiliations

  1. Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School/Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Masaharu Takigawa

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Hutchenreuther, J., Leask, A., Thompson, K. (2017). Studying the CCN Proteins in Fibrosis. In: Takigawa, M. (eds) CCN Proteins. Methods in Molecular Biology, vol 1489. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6430-7_35

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  • DOI: https://doi.org/10.1007/978-1-4939-6430-7_35

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6428-4

  • Online ISBN: 978-1-4939-6430-7

  • eBook Packages: Springer Protocols

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