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Resources for Systems Genetics

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Systems Genetics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1488))

Abstract

A key characteristic of systems genetics is its reliance on populations that vary to a greater or lesser degree in genetic complexity—from highly admixed populations such as the Collaborative Cross and Diversity Outcross to relatively simple crosses such as sets of consomic strains and reduced complexity crosses. This protocol is intended to help investigators make more informed decisions about choices of resources given different types of questions. We consider factors such as costs, availability, and ease of breeding for common scenarios. In general, we recommend using complementary resources and minimizing depth of resampling of any given genome or strain.

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Acknowledgments

We thank the support of the UT Center for Integrative and Translational Genomics, and funds from the UT-ORNL Governor’s Chair.

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Authors and Affiliations

  1. Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, 77 S. Manassas Street, Memphis, TN, 38163, USA

    Robert W. Williams Ph.D.

  2. Department of Biology, Institute for Molecular Systems Biology, ETH Zürich, Zürich, Switzerland

    Evan G. Williams

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  1. Robert W. Williams Ph.D.
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Correspondence to Robert W. Williams Ph.D. .

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Editors and Affiliations

  1. Department of Infection Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine Hannover, Braunschweig, Niedersachsen, Germany

    Klaus Schughart

  2. Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA

    Robert W. Williams

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Williams, R.W., Williams, E.G. (2017). Resources for Systems Genetics. In: Schughart, K., Williams, R. (eds) Systems Genetics. Methods in Molecular Biology, vol 1488. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6427-7_1

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  • DOI: https://doi.org/10.1007/978-1-4939-6427-7_1

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