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Microencapsulation in Clinical Islet Xenotransplantation

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Book cover Cell Microencapsulation

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1479))

Abstract

Allogeneic islet transplantation has become a viable treatment for patients with unstable type 1 diabetes; however, donor shortage and the necessity for immunosuppressive drugs are the major drawbacks of this approach. Microencapsulated porcine islet xenotransplantation could solve these drawbacks. Clinical porcine islet xenotransplantation as well as microencapsulated islet transplantation has been conducted without significant side effects. However, these transplantations are not as efficacious as allogeneic naked islet transplantation. High quality porcine islets, biocompatible capsules, and appropriate implant sites should be the key factors for improving efficacy. With improved efficacy, microencapsulated islet xenotransplantation will solve the major drawbacks associated with current islet transplantation.

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Author information

Authors and Affiliations

  1. National Institute for Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan

    Masayuki Shimoda

  2. National Center for Global Health and Medicine, Tokyo, Japan

    Shinichi Matsumoto M.D., Ph.D.

  3. Otsuka Pharmaceutical Factory Inc., Naruto, Japan

    Shinichi Matsumoto M.D., Ph.D.

Authors
  1. Masayuki Shimoda
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  2. Shinichi Matsumoto M.D., Ph.D.
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Corresponding author

Correspondence to Shinichi Matsumoto M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Wake Forest Institute for Regenerative Medicine Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

    Emmanuel C. Opara

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Shimoda, M., Matsumoto, S. (2017). Microencapsulation in Clinical Islet Xenotransplantation. In: Opara, E. (eds) Cell Microencapsulation. Methods in Molecular Biology, vol 1479. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6364-5_25

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  • DOI: https://doi.org/10.1007/978-1-4939-6364-5_25

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6362-1

  • Online ISBN: 978-1-4939-6364-5

  • eBook Packages: Springer Protocols

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