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The Blood–Brain Barrier and the Design of New Antiepileptic Drugs

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Antiepileptic Drug Discovery

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

The vertebrate’s brain is vascularized during its development to provide oxygen and essential nutrients to newly born neurons. This brain vasculature is anatomically distinct from that of other organs. It comprises, in addition to endothelial cells, pericytes and astrocytes, which collectively form the neurovascular unit, structure that underlies the blood–brain barrier and regulates blood flow to match brain activity. The main features of the vertebrate blood–brain barrier are closed cell–cell junctions, a low rate of transcytosis, and the expression of various adenosine triphosphate-binding cassette transporters. The blood–brain barrier function is impaired in several neurological diseases including epilepsy. This chapter will provide a brief overview on the regulation of blood–brain barrier properties by the neurovascular unit and the relation between blood–brain barrier, seizures, and epilepsy. We will also summarize new therapies that aim to control seizure activity.

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Authors and Affiliations

  1. Department of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA

    Gabriela Rogel-Salazar & Hiram Luna-Munguia Ph.D.

Authors
  1. Gabriela Rogel-Salazar
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  2. Hiram Luna-Munguia Ph.D.
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Correspondence to Hiram Luna-Munguia Ph.D. .

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Editors and Affiliations

  1. Laboratorio de Investigación y Desarrollo de Bioactivos (LIDeB) Faculty of Exact Sciences, National University of La Plata, La Plata, Buenos Aires, Argentina

    Alan Talevi

  2. Department of Pharmacobiology, Center for Research and Advanced Studies, Mexico City, Mexico

    Luisa Rocha

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Rogel-Salazar, G., Luna-Munguia, H. (2016). The Blood–Brain Barrier and the Design of New Antiepileptic Drugs. In: Talevi, A., Rocha, L. (eds) Antiepileptic Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6355-3_12

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  • DOI: https://doi.org/10.1007/978-1-4939-6355-3_12

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6353-9

  • Online ISBN: 978-1-4939-6355-3

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