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Rodent Models of Stroke pp 31–43Cite as

Focal Cerebral Ischemia in the Mouse and Rat by Intraluminal Suture

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Part of the book series: Neuromethods ((NM,volume 120))

Abstract

Filamentous occlusion of the middle cerebral artery (MCA) is probably the most frequently used model in experimental stroke research. It results in reproducible lesions in the cortex and striatum and can be used to induce both permanent and transient MCA occlusion (MCAo). It allows for the study of both acute stroke treatment as well as interventions that target stroke recovery. This chapter gives a practical “hands-on” approach for performing this model in mice and rats.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Neurology and Neuroscience, LSUHSC Neuroscience Center, 2020 Gravier Street, Suite 9B4, Room 935A, New Orleans, LA, 70112, USA

    Ludmila Belayev M.D.

  2. Department of Neurology and Experimental Neurology, Center for Stroke Research Berlin, Charite Universitätsmedizin Berlin, 10117, Berlin, Germany

    Matthias Endres & Vincent Prinz

  3. Department of Neurosurgery, Charite Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Vincent Prinz

Authors
  1. Ludmila Belayev M.D.
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  2. Matthias Endres
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  3. Vincent Prinz
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Corresponding author

Correspondence to Ludmila Belayev M.D. .

Editor information

Editors and Affiliations

  1. Department of Experimental Neurology and Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, Germany

    Ulrich Dirnagl

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Belayev, L., Endres, M., Prinz, V. (2016). Focal Cerebral Ischemia in the Mouse and Rat by Intraluminal Suture. In: Dirnagl, U. (eds) Rodent Models of Stroke. Neuromethods, vol 120. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-5620-3_4

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  • DOI: https://doi.org/10.1007/978-1-4939-5620-3_4

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-5618-0

  • Online ISBN: 978-1-4939-5620-3

  • eBook Packages: Springer Protocols

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