Abstract
Monoclonal antibodies (mAbs) are widely used in cancer therapy and recently many new mAbs have gained EMA and FDA approvals for oncology indications. Here we describe a highly reproducible CZE method, relying on a cationic coating allowing separation and identification of a complex mixture of four compounded mAbs widely used in cancer therapy (cetuximab, rituximab, bevacizumab, and trastuzumab).
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Jaccoulet, E., Smadja, C., Taverna, M. (2016). Quality Control of Therapeutic Monoclonal Antibodies at the Hospital After Their Compounding and Before Their Administration to Patients. In: Tran, N., Taverna, M. (eds) Capillary Electrophoresis of Proteins and Peptides. Methods in Molecular Biology, vol 1466. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-4014-1_14
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DOI: https://doi.org/10.1007/978-1-4939-4014-1_14
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-4012-7
Online ISBN: 978-1-4939-4014-1
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