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Clinical Traumatic Brain Injury in the Preclinical Setting

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Injury Models of the Central Nervous System

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1462))

Abstract

Traumatic brain injury (TBI) is the leading cause of death and disability for people under 45 years of age. Clinical TBI is often the result of disparate forces resulting in heterogeneous injuries. Preclinical modeling of TBI is a vital tool for studying the complex cascade of metabolic, cellular, and molecular post-TBI events collectively termed secondary injury. Preclinical models also provide an important platform for studying therapeutic interventions. However, modeling TBI in the preclinical setting is challenging, and most models replicate only certain aspects of clinical TBI. This chapter details the most widely used models of preclinical TBI, including the controlled cortical impact, fluid percussion, blast, and closed head models. Each of these models replicates particular critical aspects of clinical TBI. Prior to selecting a preclinical TBI model, it is important to address what aspect of human TBI is being sought to evaluate.

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Authors and Affiliations

  1. Division of Emergency Medicine, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA

    Justin Berkner, Rebekah Mannix M.D., M.P.H. & Jianhua Qiu M.D., Ph.D.

  2. Harvard Medical School, Boston, MA, USA

    Rebekah Mannix M.D., M.P.H. & Jianhua Qiu M.D., Ph.D.

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  1. Justin Berkner
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  2. Rebekah Mannix M.D., M.P.H.
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  3. Jianhua Qiu M.D., Ph.D.
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Correspondence to Rebekah Mannix M.D., M.P.H. .

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Editors and Affiliations

  1. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Firas H. Kobeissy

  2. Safar Center for Resuscitation Research, University of Pittsburgh Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA

    C. Edward Dixon

  3. Banyan Biomarkers, Inc. , Alachua, Florida, USA

    Ronald L. Hayes

  4. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Stefania Mondello

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Berkner, J., Mannix, R., Qiu, J. (2016). Clinical Traumatic Brain Injury in the Preclinical Setting. In: Kobeissy, F., Dixon, C., Hayes, R., Mondello, S. (eds) Injury Models of the Central Nervous System. Methods in Molecular Biology, vol 1462. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3816-2_2

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  • DOI: https://doi.org/10.1007/978-1-4939-3816-2_2

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