Abstract
The development of coelenterazine (CTZ) derivatives resulting in superior optical characteristics is an efficient method to extend the range of its possible applications. Here, we describe the synthesis of three C-6 substituted CTZ derivatives retaining the recognition by Renilla luciferase (RLuc) and its derivatives. The novel derivatives are useful as bright blue-shifted CTZ derivatives, which can be used as an alternative to hitherto reported compound DeepBlueC™.
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Acknowledgement
This work was supported by JSPS KAKENHI Grant Number 24225001.
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Nishihara, R., Citterio, D., Suzuki, K. (2016). Synthetic Bioluminescent Coelenterazine Derivatives. In: Kim, S. (eds) Bioluminescence. Methods in Molecular Biology, vol 1461. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3813-1_2
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DOI: https://doi.org/10.1007/978-1-4939-3813-1_2
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