Abstract
The zebrafish is a widely accepted model to study leukemia. The major advantage of studying leukemogenesis in zebrafish is attributed to its short life cycle and superior imaging capacity. This chapter highlights using transgenic- and xenograft-based models in zebrafish to study a specific leukemogenic mutation and analyze therapeutic responses in vivo.
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Acknowledgments
The authors would like to acknowledge members of Berman and Dellaire lab especially Dale Corkery, Chansey Veinotte, Sergey Prykhozhij, Nicole Melong, Babak Razaghi, Jaime Wertman, and Victoria Bentley for the critical review. Vinothkumar Rajan is funded through Cancer Research Trainee Program of the Beatrice Hunter Cancer Institute, Nova Scotia in partnership with the Canadian Imperial bank of Commerce and New Brunswick Health Research Foundation.
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Rajan, V., Dellaire, G., Berman, J.N. (2016). Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models. In: Kawakami, K., Patton, E., Orger, M. (eds) Zebrafish. Methods in Molecular Biology, vol 1451. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3771-4_12
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DOI: https://doi.org/10.1007/978-1-4939-3771-4_12
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