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The Nuclear Receptor Superfamily pp 3–9Cite as

The Nuclear Receptor Superfamily at Thirty

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1443))

Abstract

The human genome codes for 48 members of the nuclear receptor superfamily, half of which have known ligands. Natural ligands for nuclear receptors are generally lipophilic in nature and include steroid hormones, bile acids, fatty acids, thyroid hormones, certain vitamins, and prostaglandins. Nuclear receptors regulate gene expression programs controlling development, differentiation, metabolic homeostasis and reproduction, in both a temporal and a tissue-selective manner. Since the original cloning of the cDNAs for the estrogen and glucocorticoid receptors, large strides have been made in our understanding of the structure and function of this family of transcription factors and their role in pathophysiology.

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Authors and Affiliations

  1. School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK

    Iain J. McEwan

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  1. Iain J. McEwan
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Correspondence to Iain J. McEwan .

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Editors and Affiliations

  1. Ins. of Med. Sci. Uni. of Aberdeen, Sch. of Medicine Med. Sci. and Nutrition, Aberdeen, United Kingdom

    Iain J. McEwan, PhD

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McEwan, I.J. (2016). The Nuclear Receptor Superfamily at Thirty. In: McEwan, PhD, I. (eds) The Nuclear Receptor Superfamily. Methods in Molecular Biology, vol 1443. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3724-0_1

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  • DOI: https://doi.org/10.1007/978-1-4939-3724-0_1

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3722-6

  • Online ISBN: 978-1-4939-3724-0

  • eBook Packages: Springer Protocols

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