Instrument Quality Control

  • Chatura JayakodyEmail author
  • Emily A. Hull-Ryde
Part of the Methods in Molecular Biology book series (MIMB, volume 1439)


Well-defined quality control (QC) processes are used to determine whether a certain procedure or action conforms to a widely accepted standard and/or set of guidelines, and are important components of any laboratory quality assurance program (Popa-Burke et al., J Biomol Screen 14: 1017–1030, 2009). In this chapter, we describe QC procedures useful for monitoring the accuracy and precision of laboratory instrumentation, most notably automated liquid dispensers. Two techniques, gravimetric QC and photometric QC, are highlighted in this chapter. When used together, these simple techniques provide a robust process for evaluating liquid handler accuracy and precision, and critically underpin high-quality research programs.

Key words

Quality control Liquid-handling variability Assay performance High-throughput screening QC Gravimetric quality control Photometric quality control 



We would like to thank Catherine Simpson and Alice Cheng for technical support; and Drs. Kenneth Pearce and Stephen Frye, and William Janzen for manuscript advice.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Warp Drive BioCambridgeUSA
  2. 2.Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of PharmacyUniversity of North CarolinaChapel HillUSA

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