Instrument Quality Control
Well-defined quality control (QC) processes are used to determine whether a certain procedure or action conforms to a widely accepted standard and/or set of guidelines, and are important components of any laboratory quality assurance program (Popa-Burke et al., J Biomol Screen 14: 1017–1030, 2009). In this chapter, we describe QC procedures useful for monitoring the accuracy and precision of laboratory instrumentation, most notably automated liquid dispensers. Two techniques, gravimetric QC and photometric QC, are highlighted in this chapter. When used together, these simple techniques provide a robust process for evaluating liquid handler accuracy and precision, and critically underpin high-quality research programs.
Key wordsQuality control Liquid-handling variability Assay performance High-throughput screening QC Gravimetric quality control Photometric quality control
We would like to thank Catherine Simpson and Alice Cheng for technical support; and Drs. Kenneth Pearce and Stephen Frye, and William Janzen for manuscript advice.
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