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Mouse Models for Studying Depression-Like States and Antidepressant Drugs

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Mouse Models for Drug Discovery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1438))

Abstract

Depression is a common psychiatric disorder, with diverse symptoms and high comorbidity with other brain dysfunctions. Due to this complexity, little is known about the neural and genetic mechanisms involved in depression pathogenesis. In a large proportion of patients, current antidepressant treatments are often ineffective and/or have undesirable side effects, fueling the search for more effective drugs. Animal models mimicking various symptoms of depression are indispensable in studying the biological mechanisms of this disease. Here, we summarize several popular methods for assessing depression-like symptoms in mice, and their utility in screening antidepressant drugs.

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Acknowledgements

This work was supported by NARSAD YI Award to AVK, and by Stress Physiology and Research Center (SPaRC) of Georgetown University Medical School. AVK is the President of the International Stress and Behavior Society (ISBS, www.stressandbehavior.com). He is supported by Guangdong Ocean University, St. Petersburg State University (internal grant 1.38.201.2014) and Ural Federal University (Government of Russian Federation Act 211, contract 02-A03.21.0006).

Author information

Authors and Affiliations

  1. Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC, 20057, USA

    Carisa L. Bergner, Amanda N. Smolinsky, Peter C. Hart, Rupert J. Egan, Justin L. LaPorte & Allan V. Kalueff Ph.D.

  2. Department of Animal Sciences, Purdue University, 915 W State St., West Lafayette, IN, 47907, USA

    Brett D. Dufour

  3. Stress Physiology and Research Center (SPaRC), Georgetown University Medical Center, 3900 Reservoir Road, Washington, DC, 20057, USA

    Justin L. LaPorte & Allan V. Kalueff Ph.D.

  4. Department of Pharmacology, Tulane University Medical Center, 830 Tulane Avenue, New Orleans, LA, 70112, USA

    Allan V. Kalueff Ph.D.

  5. Department of Physiology and Biophysics, Georgetown University Medical School, Basic Science Building, Room 254, 3900 Reservoir Road, Washington, DC, 20057, USA

    Allan V. Kalueff Ph.D.

  6. Research Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, 340111, China

    Allan V. Kalueff Ph.D.

  7. Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, 196310, Russia

    Allan V. Kalueff Ph.D.

  8. ZENEREI Research Center, Slidell, LA, 70458, USA

    Allan V. Kalueff Ph.D.

  9. Chemicotechnological Institute, Ural Federal State University , Ekaterinburg, 620002, Russia

    Allan V. Kalueff Ph.D.

Authors
  1. Carisa L. Bergner
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  2. Amanda N. Smolinsky
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  3. Peter C. Hart
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  4. Brett D. Dufour
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  5. Rupert J. Egan
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  6. Justin L. LaPorte
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  7. Allan V. Kalueff Ph.D.
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Corresponding author

Correspondence to Allan V. Kalueff Ph.D. .

Editor information

Editors and Affiliations

  1. Takeda Pharmaceutical Company, Cambridge, Massachusetts, USA

    Gabriele Proetzel

  2. The Jackson Laboratory, Bar Harbor, Maine, USA

    Michael V. Wiles

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Bergner, C.L. et al. (2016). Mouse Models for Studying Depression-Like States and Antidepressant Drugs. In: Proetzel, G., Wiles, M. (eds) Mouse Models for Drug Discovery. Methods in Molecular Biology, vol 1438. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3661-8_15

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  • DOI: https://doi.org/10.1007/978-1-4939-3661-8_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3659-5

  • Online ISBN: 978-1-4939-3661-8

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