Abstract
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.
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Acknowledgments
This work was supported by a Veterans Affairs Merit Award (LMO), as well as NIH Grants CA084197 and DK052230 (VWY), and CA172517 and CA097132 (YAH).
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Snider, A.J., Bialkowska, A.B., Ghaleb, A.M., Yang, V.W., Obeid, L.M., Hannun, Y.A. (2016). Murine Model for Colitis-Associated Cancer of the Colon. In: Proetzel, G., Wiles, M. (eds) Mouse Models for Drug Discovery. Methods in Molecular Biology, vol 1438. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3661-8_14
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DOI: https://doi.org/10.1007/978-1-4939-3661-8_14
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