Abstract
Angiogenesis is an important determinant of tissue function, from delivery of oxygen and other substrates to removal of waste products, in health and disease (e.g., adaptive or pathological remodelling). The phenotype and functional responses of endothelial cells are conditioned by systemic humoral signals and local environmental factors, including the haemodynamic forces that act upon them. Here we describe some interventions that have been helpful in unraveling the integrative nature of the complex in vivo response, and quantitative assessment of angiogenesis in muscle.
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Acknowledgements
Development of the ideas in this chapter has been supported by the BBSRC, BHF, MRC, and Wellcome Trust; discussions with many colleagues and students have been extremely helpful.
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Egginton, S. (2016). In Vivo Models of Muscle Angiogenesis. In: Martin, S., Hewett, P. (eds) Angiogenesis Protocols. Methods in Molecular Biology, vol 1430. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3628-1_25
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DOI: https://doi.org/10.1007/978-1-4939-3628-1_25
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