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An Overview of Nanoparticle Based Delivery for Treatment of Inner Ear Disorders

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Auditory and Vestibular Research

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1427))

Abstract

Nanoparticles offer new possibilities for inner ear treatment as they can carry a variety of drugs, protein, and nucleic acids to inner ear. Nanoparticles are equipped with several functions such as targetability, immuno-transparency, biochemical stability, and ability to be visualized in vivo and in vitro. A group of novel peptides can be attached to the surface of nanoparticles that will enhance the cell entry, endosomal escape, and nuclear targeting. Eight different types of nanoparticles with different payload carrying strategies are available now. The transtympanic delivery of nanoparticles indicates that, depending on the type of nanoparticle, different migration pathways into the inner ear can be employed, and that optimal carriers can be designed according to the intended cargo. The use of nanoparticles as drug/gene carriers is especially attractive in conjunction with cochlear implantation or even as an inclusion in the implant as a drug/gene reservoir.

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Acknowledgments

HEI-OCI immortalized hair cell line (kindly provided by Prof. Federico Kalinec). Dr. Anna Minasyan kindly helped in structuring the manuscript. This project is supported by EU NanoEar Integrated Project NMP4-CT-2006-026556. We also acknowledge Kellomäki Minna (Tampere University of Technology), Linden Mika (Åbo Akademi University), Vihinen-Ranta Maija (Univeristy of Jyväskylä), Muhammed Mamoun (Royal Institute of Technology), Möller Martin and Kroll Juergen (RWTH, Aachen), Saulnier Patrick (Université d'Angers-INSERM U646), Stöver Timo (Medizinische Hochschule Hannover), Klok Harm-Anton (Ecole Polytechnique Fédérale de Lausanne), Popelar Jiri (Institute of Experimental Medicine, Prague), Rask-Andersen Helge (Uppsala University Hospital), Lianos Elias (University of Athens School of Medicine), Newman Tracey (University of Southampton), Jolly Claude (MED-EL Corporation, Austria), and Löbler Marian (University of Rostock) for their comments and contributions to this work.

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Authors and Affiliations

  1. Department of Otolaryngology, University of Tampere and University Hospital of Tampere, Tampere, 33014, Finland

    Ilmari Pyykkö

  2. Hearing and Balance Research Unit, Field of Otolaryngology, School of Medicine, University of Tampere, Medisiinarinkatu 3, Tampere, 33520, Finland

    Ilmari Pyykkö

  3. Department of Otolaryngology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria

    Annelies Schrott-Fischer & Rudolf Glueckert

  4. BECS, Department of Biomedical Engineering and Computational Science, Aalto University, Aalto, Finland

    Paavo Kinnunen

  5. BECS, Department of Biomedical Engineering and Computational Science, Aalto University, Aalto, 02150, Espoo, Finland

    Jing Zou

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  1. Ilmari Pyykkö
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  2. Jing Zou
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  3. Annelies Schrott-Fischer
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  4. Rudolf Glueckert
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  5. Paavo Kinnunen
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Correspondence to Ilmari Pyykkö .

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  1. College of Medicine, University of South Florida, Tampa, Florida, USA

    Bernd Sokolowski

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Pyykkö, I., Zou, J., Schrott-Fischer, A., Glueckert, R., Kinnunen, P. (2016). An Overview of Nanoparticle Based Delivery for Treatment of Inner Ear Disorders. In: Sokolowski, B. (eds) Auditory and Vestibular Research. Methods in Molecular Biology, vol 1427. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3615-1_21

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  • DOI: https://doi.org/10.1007/978-1-4939-3615-1_21

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3613-7

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