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Detection of Apoptosis: From Bench Side to Clinical Practice

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Book cover Apoptosis Methods in Toxicology

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

Apoptosis or programmed cell death is implicated in several pathological conditions, such as cancer and neurodegenerative diseases. An increasing number of therapies are developed by targeting apoptosis signaling components to either induce or inhibit apoptosis in target cells. For these reasons, it is critical to develop appropriate analytical methods for the detection of apoptotic cell death in the context of monitoring relevant disease progression and therapeutic effects of clinical treatments (e.g., chemotherapy in cancer patients). This review provides an overview of the currently used methods for detection of apoptosis and their applications in research and clinical practice.

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  1. Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Bldg. 52/72, Rm. 2128, Silver Spring, MD, 20993, USA

    William P. Bozza, Julianne D. Twomey, Su-Ryun Kim & Baolin Zhang

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  1. William P. Bozza
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  2. Julianne D. Twomey
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  3. Su-Ryun Kim
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  4. Baolin Zhang
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Correspondence to Baolin Zhang .

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  1. Department of Biology, North Carolina A&T State University, Greensboro, North Carolina, USA

    Perpetua M. Muganda

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Bozza, W.P., Twomey, J.D., Kim, SR., Zhang, B. (2016). Detection of Apoptosis: From Bench Side to Clinical Practice. In: Muganda, P. (eds) Apoptosis Methods in Toxicology. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3588-8_2

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  • DOI: https://doi.org/10.1007/978-1-4939-3588-8_2

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