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Active and Passive Immunotherapy Against Tau: Effects and Potential Mechanisms

  • Kiran Yanamandra
  • Marc I. Diamond
  • David M. HoltzmanEmail author
Protocol
Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Abstract

The aggregation, hyperphosphorylation, and accumulation of the microtubule-associated protein tau is a hallmark for several neurodegenerative diseases, including Alzheimer’s disease. These diseases are known as tauopathies. In tauopathies, the tau protein becomes hyperphosphorylated and forms intracellular neurofibrillary tangles visualized within dystrophic neurites and cell bodies. Evidence suggests that some tau aggregates can become extracellular where they potentially propagate between cells and induce tau pathology in previously unaffected cells. The amount of tau pathology correlates well with the load of neurofibrillary tangles, synaptic loss, and functional decline in humans as well as in transgenic mouse models of tauopathy. Several active and passive immunization studies targeting tau in transgenic mouse models have shown reduced tau pathology, although the mechanism(s) underlying these effects is not clear. In this chapter, we review the recent active and passive immunization strategies targeting tau in mouse models and our understanding of potential mechanisms underlying the effects seen.

Key words

Tau Immunotherapy Alzheimer’s disease Neurodegeneration Antibody 

Notes

Acknowledgements

This work was supported by research grants from the Tau consortium and C2N Diagnostics (M.I.D. and D.M.H.).

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Kiran Yanamandra
    • 1
  • Marc I. Diamond
    • 2
  • David M. Holtzman
    • 1
    Email author
  1. 1.Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research CenterWashington University School of MedicineSt. LouisUSA
  2. 2.Department of Neurology and NeurotherapeuticsUniversity of Texas, Southwestern Medical CenterDallasUSA

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