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Tau Immunotherapy

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Immunotherapy and Biomarkers in Neurodegenerative Disorders

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

Great strides have been made in recent years on the development of tau immunotherapies for Alzheimer’s disease and other tauopathies. Multiple animal studies by several groups have shown efficacy of various active and passive approaches in reducing pathological tau proteins. Clinical trials are clearly warranted and a few have already been initiated. However, much remains to be clarified regarding the mechanisms of action and how efficacy can be improved and potential toxicity minimized. These are exciting times for the field and will hopefully lead to an effective therapy in the near future.

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Acknowledgements

E.M.S. is supported by NIH grants NS077239, AG032611, and AG020197. He is an inventor on patents on tau immunotherapy and related diagnostics that are assigned to New York University. This technology is licensed to and is being co-developed with H. Lundbeck A/S.

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Authors and Affiliations

  1. Department of Neuroscience and Physiology, New York University School of Medicine, Medical Science Building, MSB459, 550 First Avenue, New York, NY, 10016, USA

    Einar M. Sigurdsson Ph.D.

  2. Department of Psychiatry, New York University School of Medicine, Medical Science Building, MSB459, 550 First Avenue, New York, NY, 10016, USA

    Einar M. Sigurdsson Ph.D.

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  1. Einar M. Sigurdsson Ph.D.
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Correspondence to Einar M. Sigurdsson Ph.D. .

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Editors and Affiliations

  1. Dept Public Health & Caring Sci Ger, Uppsala University, Uppsala, Sweden

    Martin Ingelsson

  2. Dept Public Health & Caring Sci Ger, Uppsala University, Uppsala, Sweden

    Lars Lannfelt

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Sigurdsson, E.M. (2016). Tau Immunotherapy. In: Ingelsson, M., Lannfelt, L. (eds) Immunotherapy and Biomarkers in Neurodegenerative Disorders. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3560-4_8

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  • DOI: https://doi.org/10.1007/978-1-4939-3560-4_8

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