Tau Immunotherapy

  • Einar M. SigurdssonEmail author
Part of the Methods in Pharmacology and Toxicology book series (MIPT)


Great strides have been made in recent years on the development of tau immunotherapies for Alzheimer’s disease and other tauopathies. Multiple animal studies by several groups have shown efficacy of various active and passive approaches in reducing pathological tau proteins. Clinical trials are clearly warranted and a few have already been initiated. However, much remains to be clarified regarding the mechanisms of action and how efficacy can be improved and potential toxicity minimized. These are exciting times for the field and will hopefully lead to an effective therapy in the near future.

Key words

Tau Immunotherapy Alzheimer’s disease Tauopathies Neurofibrillary tangles Immunization Vaccine Aggregates 



E.M.S. is supported by NIH grants NS077239, AG032611, and AG020197. He is an inventor on patents on tau immunotherapy and related diagnostics that are assigned to New York University. This technology is licensed to and is being co-developed with H. Lundbeck A/S.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Neuroscience and PhysiologyNew York University School of MedicineNew YorkUSA
  2. 2.Department of PsychiatryNew York University School of MedicineNew YorkUSA

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