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Active Immunization Against the Amyloid-β Peptide

  • Enchi LiuEmail author
  • J. Michael Ryan
Protocol
Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Abstract

Alzheimer’s disease (AD) has a devastating toll not only on the affected individuals but also on their families, caregivers, and society as a whole. Several therapies have been approved to treat AD, all of which provide modest effect on the symptoms of the illness but without slowing or halting the underlying disease processes. Since the last of these therapies was approved, the largest research effort has been devoted to developing therapies targeting amyloid-β, specifically Aβ42, as this protein is thought to initiate the cascade of events that lead to the disease. This chapter focuses on active immunotherapy (vaccines) and specifically on therapies that currently are in clinical development.

Key words

Alzheimer’s disease Amyloid-β Active immunotherapy Therapeutic vaccine 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Prothena Biosciences, Inc.South San FranciscoUSA
  2. 2.Novartis Pharmaceuticals CorporationEast HanoverUSA

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