Alpha-Synuclein as a Diagnostic Biomarker for Parkinson’s Disease

  • Joakim Bergström
  • Martin IngelssonEmail author
Part of the Methods in Pharmacology and Toxicology book series (MIPT)


The development of new biomarkers for Parkinson’s disease has been focused on the analyses of the α-synuclein protein in cerebrospinal fluid and plasma. Although significant differences in the levels of total α-synuclein have been found between patients and controls, none of these markers have been proven clinically useful as there has been a substantial overlap between the groups. Instead, assessment of toxic prefibrillar α-synuclein species has shown promising results, but further studies are needed to prove their diagnostic usefulness. In addition to analyses of body fluids, detection of α-synuclein in peripheral tissues—such as subcolonic mucosa and parotid gland—seem to offer novel interesting diagnostic possibilities.

Key words

ELISA α-Synuclein Plasma Cerebrospinal fluid Colon mucosa Parotid gland 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Public Health & Caring Sciences/GeriatricsUppsala UniversityUppsalaSweden

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