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Oral Vaccine Development by Molecular Display Methods Using Microbial Cells

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Book cover Vaccine Design

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1404))

Abstract

Oral vaccines are easier to administer than injectable vaccines. To induce an adequate immune response using vaccines, antigenic proteins are usually combined with adjuvant materials. This chapter presents methodologies for the design of oral vaccines using molecular display technology. In molecular display technology, antigenic proteins are displayed on a microbial cell surface with adjuvant ability. This technology would provide a quite convenient process to produce oral vaccines when the DNA sequence of an efficient antigenic protein is available. As an example, oral vaccines against candidiasis were introduced using two different molecular display systems with Saccharomyces cerevisiae and Lactobacillus casei.

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Acknowledgements

We thank Miki Karasaki for the preparation of figures. This chapter described the work supported by the regional innovation creation R&D programs of the Ministry of Economy, Trade and Industry, Japan (22R5005).

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Authors and Affiliations

  1. General Education Center and Graduate School of Pharmacy, Hyogo University of Health Sciences, 1-3-6 Minatojima, Chuo-ku, Kobe, 650-8530, Japan

    Seiji Shibasaki

  2. Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan

    Mitsuyoshi Ueda

Authors
  1. Seiji Shibasaki
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  2. Mitsuyoshi Ueda
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Corresponding author

Correspondence to Seiji Shibasaki .

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Editors and Affiliations

  1. Lankenau Institute for Medical Research, Wynnewood, PA, USA

    Sunil Thomas

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Shibasaki, S., Ueda, M. (2016). Oral Vaccine Development by Molecular Display Methods Using Microbial Cells. In: Thomas, S. (eds) Vaccine Design. Methods in Molecular Biology, vol 1404. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-3389-1_32

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  • DOI: https://doi.org/10.1007/978-1-4939-3389-1_32

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-3388-4

  • Online ISBN: 978-1-4939-3389-1

  • eBook Packages: Springer Protocols

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