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Principles of Vaccination

  • Fred Zepp
Part of the Methods in Molecular Biology book series (MIMB, volume 1403)

Abstract

While many of the currently available vaccines have been developed empirically, with limited understanding on how they activate the immune system and elicit protective immunity, the recent progress in basic sciences like immunology, microbiology, genetics, and molecular biology has fostered our understanding on the interaction of microorganisms with the human immune system. In consequence, modern vaccine development strongly builds on the precise knowledge of the biology of microbial pathogens, their interaction with the human immune system, as well as their capacity to counteract and evade innate and adaptive immune mechanisms. Strategies engaged by pathogens strongly determine how a vaccine should be formulated to evoke potent and efficient protective immune responses. The improved knowledge of immune response mechanisms has facilitated the development of new vaccines with the capacity to defend against challenging pathogens and can help to protect individuals particular at risk like immunocompromised and elderly populations. Modern vaccine development technologies include the production of highly purified antigens that provide a lower reactogenicity and higher safety profile than the traditional empirically developed vaccines. Attempts to improve vaccine antigen purity, however, may result in impaired vaccine immunogenicity. Some of such disadvantages related to highly purified and/or genetically engineered vaccines yet can be overcome by innovative technologies, such as live vector vaccines, and DNA or RNA vaccines. Moreover, recent years have witnessed the development of novel adjuvant formulations that specifically focus on the augmentation and/or control of the interplay between innate and adaptive immune systems as well as the function of antigen-presenting cells. Finally, vaccine design has become more tailored, and in turn has opened up the potential of extending its application to hitherto not accessible complex microbial pathogens plus providing new immunotherapies to tackle diseases such as cancer, Alzheimer’s disease, and autoimmune disease. This chapter gives an overview of the key considerations and processes involved in vaccine development. It also describes the basic principles of normal immune respoinses and its their function in defense of infectious agents by vaccination.

Key words

Vaccine Vaccination Immunology Pathogen T cell B cell Infectious disease 

References

  1. 1.
    Zepp F (2010) Principles of vaccine design—lessons from nature. Vaccine 28 Suppl 3:C14–C24Google Scholar
  2. 2.
    Plotkin SL, Plotkin SA (2012) A short history of vaccination. In: Plotkin SA, Orenstein WA, Offit PA (eds) Vaccines, 6th edn. Saunders, Philadelphia, pp 1–16Google Scholar
  3. 3.
    Kelly DF, Rappuoli R (2005) Reverse vaccinology and vaccines for serogroup B Neisseria meningitidis. Adv Exp Med Biol 568:217–223CrossRefPubMedGoogle Scholar
  4. 4.
    Leroux-Roels G (2010) Unmet needs in modern vaccinology: adjuvants to improve the immune response. Vaccine 28 Suppl 3:C25–C36Google Scholar
  5. 5.
    Girard MP, Steele D, Chaignat CL et al (2006) A review of vaccine research and development: human enteric infections. Vaccine 24:2732–2750CrossRefPubMedGoogle Scholar
  6. 6.
    Edwards KM, Decker MD (2008) Pertussis vaccines. In: Plotkin SA, Orenstein WA, Offit PA (eds) Vaccines, 5th edn. Elsevier, New York, pp 467–518Google Scholar
  7. 7.
    Bridges CB, Katz JM, Levandowski RA et al (2008) Inactivated influenza vaccines. In: Plotkin SA, Orenstein WA, Offit PA (eds) Vaccines, 5th edn. Elsevier, New York, pp 259–290Google Scholar
  8. 8.
    World Health Organization (2003) Introduction of inactivated poliovirus vaccine into oral poliovirus vaccine-using countries. Wkly Epidemiol Rec 78:241–250Google Scholar
  9. 9.
    Demicheli V, Debalini MG, Rivetti A (2009) Vaccines for preventing tick-borne encephalitis. Cochrane Database Syst Rev (1):CD000977Google Scholar
  10. 10.
    Fiore AE, Feinstone FM, Bell BP (2008) Hepatitis A vaccines. In: Plotkin SA, Orenstein WA, Offit PA (eds) Vaccines, 5th edn. Elsevier, New York, pp 177–204Google Scholar
  11. 11.
    Sutter RW, Kew OM, Cochi SL (2008) Poliovirus vaccine—live. In: Plotkin SA, Orenstein WA, Offit PA (eds) Vaccines, 5th edn. Elsevier, New York, pp 631–686Google Scholar
  12. 12.
    Vesikari T, Sadzot-Delvaux C, Rentier B et al (2007) Increasing coverage and efficiency of measles, mumps, and rubella vaccine and introducing universal varicella vaccination in Europe: a role for the combined vaccine. Pediatr Infect Dis J 26:632–638CrossRefPubMedGoogle Scholar
  13. 13.
    Orme IM (2015) Tuberculosis vaccine types and timings. Clin Vaccine Immunol 22:249–257CrossRefPubMedGoogle Scholar
  14. 14.
    Siegrist CA (2012) Vaccine immunology. In: Plotkin SA, Orenstein WA, Offit PA (eds) Vaccines, 6th edn. Saunders Elsevier, Philadelphia, pp 18–36Google Scholar
  15. 15.
    Hoebe K, Janssen E, Beutler B (2004) The interface between innate and adaptive immunity. Nat Immunol 5:971–974CrossRefPubMedGoogle Scholar
  16. 16.
    Moser M, Leo O (2010) Key concepts in immunology. Vaccine 28 Suppl 3:C2–C13Google Scholar
  17. 17.
    Barton GM, Medzhitov R (2002) Toll-like receptors and their ligands. Curr Top Microbiol Immunol 270:81–92PubMedGoogle Scholar
  18. 18.
    Merle NS, Noe R, Halbwachs-Mecarelli L et al (2015) Complement system part II: role in immunity. Front Immunol 6:257PubMedPubMedCentralGoogle Scholar
  19. 19.
    Leo O, Cunningham A, Stern PL (2011) Vaccine immunology. Perspectives Vaccinol 1:25–59CrossRefGoogle Scholar
  20. 20.
    Smith KA (2012) Toward a molecular understanding of adaptive immunity: a chronology, part I. Front Immunol 3:369PubMedPubMedCentralGoogle Scholar
  21. 21.
    Smith KA (2012) Toward a molecular understanding of adaptive immunity: a chronology, part II. Front Immunol 3:364PubMedPubMedCentralGoogle Scholar
  22. 22.
    Smith KA (2014) Toward a molecular understanding of adaptive immunity: a chronology, part III. Front Immunol 5:29PubMedPubMedCentralGoogle Scholar
  23. 23.
    Vinuesa CG, Tangye SG, Moser B et al (2005) Follicular B helper T cells in antibody responses and autoimmunity. Nat Rev Immunol 5:853–865CrossRefPubMedGoogle Scholar
  24. 24.
    Eibel H, Kraus H, Sic H et al (2014) B cell biology: an overview. Curr Allergy Asthma Rep 14:434CrossRefPubMedGoogle Scholar
  25. 25.
    Shapiro-Shelef M, Calame K (2005) Regulation of plasma-cell development. Nat Rev Immunol 5:230–242CrossRefPubMedGoogle Scholar
  26. 26.
    Deenick EK, Hasbold J, Hodgkin PD (2005) Decision criteria for resolving isotype switching conflicts by B cells. Eur J Immunol 35:2949–2955CrossRefPubMedGoogle Scholar
  27. 27.
    Gasper DJ, Tejera MM, Suresh M (2014) CD4 T-cell memory generation and maintenance. Crit Rev Immunol 34:121–146CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Takemori T, Kaji T, Takahashi Y et al (2014) Generation of memory B cells inside and outside germinal centers. Eur J Immunol 44:1258–1264CrossRefPubMedGoogle Scholar
  29. 29.
    Plotkin SA (2010) Correlates of protection induced by vaccination. Clin Vaccine Immunol 17:1055–1065CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Banatvala JE, Van DP (2003) Hepatitis B vaccine—do we need boosters? J Viral Hepat 10:1–6CrossRefPubMedGoogle Scholar
  31. 31.
    Zepp F, Knuf M, Habermehl P et al (1997) Cell-mediated immunity after pertussis vaccination and after natural infection. Dev Biol Stand 89:307–314PubMedGoogle Scholar
  32. 32.
    Mills KH, Ryan M, Ryan E et al (1998) A murine model in which protection correlates with pertussis vaccine efficacy in children reveals complementary roles for humoral and cell-mediated immunity in protection against Bordetella pertussis. Infect Immun 66:594–602PubMedPubMedCentralGoogle Scholar
  33. 33.
    Schwarz TF, Leo O (2008) Immune response to human papillomavirus after prophylactic vaccination with AS04-adjuvanted HPV-16/18 vaccine: improving upon nature. Gynecol Oncol 110(3 Suppl 1):S1–S10CrossRefPubMedGoogle Scholar
  34. 34.
    Leroux-Roels I, Leroux-Roels G (2009) Current status and progress of prepandemic and pandemic influenza vaccine development. Expert Rev Vaccines 8:401–423CrossRefPubMedGoogle Scholar
  35. 35.
    Fraser A, Goldberg E, Acosta CJ et al (2007) Vaccines for preventing typhoid fever. Cochrane Database Syst Rev 3, CD001261PubMedGoogle Scholar
  36. 36.
    Pletz MW, Maus U, Krug N et al (2008) Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species. Int J Antimicrob Agents 32:199–206CrossRefPubMedGoogle Scholar
  37. 37.
    Borrow R, Dagan R, Zepp F et al (2011) Glycoconjugate vaccines and immune interactions, and implications for vaccination schedules. Expert Rev Vaccines 10:1621–1631CrossRefPubMedGoogle Scholar
  38. 38.
    McCullers JA (2007) Evolution, benefits, and shortcomings of vaccine management. J Manag Care Pharm 13(7 Suppl B):S2–S6PubMedGoogle Scholar
  39. 39.
    André FE (1990) Overview of a 5-year clinical experience with a yeast-derived hepatitis B vaccine. Vaccine 8 Suppl: S74–S78Google Scholar
  40. 40.
    Rogers LJ, Eva LJ, Luesley DM (2008) Vaccines against cervical cancer. Curr Opin Oncol 20:570–574CrossRefPubMedGoogle Scholar
  41. 41.
    Brewer JM (2006) (How) do aluminium adjuvants work? Immunol Lett 102:10–15CrossRefPubMedGoogle Scholar
  42. 42.
    Garçon N, Van Mechelen M, Wettendorff M (2006) Development and evaluation of AS04, a novel and improved immunological adjuvant system containing MPL and aluminium salt. In: Schijns V, O’Hagan D (eds) Immunopotentiators in modern vaccines. Elsevier Academic Press, London, pp 161–177CrossRefGoogle Scholar
  43. 43.
    Alderson MR, McGowan P, Baldridge JR et al (2006) TLR4 agonists as immunomodulatory agents. J Endotoxin Res 12:313–319CrossRefPubMedGoogle Scholar
  44. 44.
    Higgins D, Marshall JD, Traquina P et al (2007) Immunostimulatory DNA as a vaccine adjuvant. Expert Rev Vaccines 6:747–759CrossRefPubMedGoogle Scholar
  45. 45.
    Garçon N, Van Mechelen M (2011) Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems. Expert Rev Vaccines 10:471–486CrossRefPubMedGoogle Scholar
  46. 46.
    Aguilar JC, Rodríguez EG (2007) Vaccine adjuvants revisited. Vaccine 25:3752–3762CrossRefPubMedGoogle Scholar
  47. 47.
    Schwendener RA (2014) Liposomes as vaccine delivery systems: a review of the recent advances. Ther Adv Vaccines 2:159–182CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Daudel D, Weidinger G, Spreng S (2007) Use of attenuated bacteria as delivery vectors for DNA vaccines. Expert Rev Vaccines 6:97–110CrossRefPubMedGoogle Scholar
  49. 49.
    Liniger M, Zuniga A, Naim HY (2007) Use of viral vectors for the development of vaccines. Expert Rev Vaccines 6:255–266CrossRefPubMedGoogle Scholar
  50. 50.
    Grunwald T, Ulbert S (2015) Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: vaccine-platforms for the battle against infectious diseases. Clin Exp Vaccine Res 4:1–10CrossRefPubMedPubMedCentralGoogle Scholar
  51. 51.
    Butterfield LH (2015) Cancer vaccines. BMJ 350:h988CrossRefPubMedPubMedCentralGoogle Scholar
  52. 52.
    Broide DH (2009) Immunomodulation of allergic disease. Annu Rev Med 60:279–291CrossRefPubMedPubMedCentralGoogle Scholar
  53. 53.
    Creticos PS, Schroeder JT, Hamilton RG et al (2006) Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 355:1445–1455CrossRefPubMedGoogle Scholar
  54. 54.
    Silva CL, Bonato VL, dos Santos-Junior RR et al (2009) Recent advances in DNA vaccines for autoimmune diseases. Expert Rev Vaccines 8:239–252CrossRefPubMedGoogle Scholar
  55. 55.
    Evans JT, Cluff CW, Johnson DA, Lacy MJ, Persing DH, Baldridge JR. Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529. Expert Rev Vaccines. 2003 Apr;2(2):219–29Google Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of PediatricsUniversity Medicine MainzMainzGermany

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