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Long Noncoding RNAs: An Overview

  • Dongmei Zhang
  • Minmin Xiong
  • Congjian Xu
  • Peng Xiang
  • Xiaomin ZhongEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1402)

Abstract

Recently an explosion in the discovery of long noncoding RNAs (lncRNAs) was obtained by high throughput sequencing. Genome-wide transcriptome analyses, in conjugation with research for epigenetic modifications of chromatins, identified a novel type of non-protein-coding transcripts longer than 200 nucleotides named lncRNAs. They are gradually emerging as functional and critical participants in many physiological processes. Here we give an overview of the characteristics, biological functions, and working mechanism for this new class of noncoding factors.

Key words

Long noncoding RNAs Epigenetic Stem cell Cancer 

Notes

Acknowledgments

This work was supported, in whole or in part, by the Recruitment Project of Hundred Person of Sun Yat-Sen University (X.Z.), National Natural Science Foundation 81302262 (X.Z.). We apologize to scientists whose work is not discussed here due to space constraints.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Dongmei Zhang
    • 1
  • Minmin Xiong
    • 2
  • Congjian Xu
    • 3
  • Peng Xiang
    • 2
  • Xiaomin Zhong
    • 2
    • 3
    Email author
  1. 1.State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China HospitalSichuan UniversityChengduChina
  2. 2.Department of Biology, Zhongshan School of Medicine, Center for Stem Cell Biology and Tissue EngineeringSun Yat-Sen UniversityGuangzhouChina
  3. 3.Shanghai Key Laboratory of Female Reproductive Endocrine Related DiseasesObstetrics & Gynecology Hospital of Fudan UniversityShanghaiChina

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