NONCODEv4: Annotation of Noncoding RNAs with Emphasis on Long Noncoding RNAs
The rapid development of high-throughput sequencing technologies and bioinformatics algorithms now enables detection and profiling of a large number of noncoding transcripts. Long noncoding RNAs (lncRNAs), which are longer than 200 nucleotides, are accumulating with important roles involved in biological processes and tissue physiology. In this chapter, we describe the use of NONCODEv4, a database that provide a comprehensive catalog of noncoding RNAs with particularly detailed annotations for lncRNAs. NONCODEv4 stores more than half million transcripts, of which more than 200,000 are lncRNAs. NONCODEv4 raises the concept of lncRNA genes and explores their expression and functions based on public transcriptome data. NONCODEv4 also integrated a series of online tools and have a web interface easy to use. NONCODEv4 is available at http://www.noncode.org/ http://www.bioinfo.org/noncode.
Key wordsSequencing lncRNA lncRNA gene Expression Function
This work was supported by National High-tech Research and Development Projects 863 [2012AA020402, 2012AA022501], National Key Basic Research and Development Program 973 [2009CB825401], Training Program of the Major Research plan of the National Natural Science Foundation of China , and National Natural Science Foundation of China . Funding for open access charge: Training Program of the Major Research plan of the National Natural Science Foundation of China .