Abstract
In vivo assessment of renal perfusion and oxygenation under (patho)physiological conditions by means of noninvasive diagnostic imaging is conceptually appealing. Blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) and quantitative parametric mapping of the magnetic resonance (MR) relaxation times T 2* and T 2 are thought to provide surrogates of renal tissue oxygenation. The validity and efficacy of this technique for quantitative characterization of local tissue oxygenation and its changes under different functional conditions have not been systematically examined yet and remain to be established. For this purpose, the development of an integrative multimodality approaches is essential. Here we describe an integrated hybrid approach (MR-PHYSIOL) that combines established quantitative physiological measurements with T 2* (T 2) mapping and MR-based kidney size measurements. Standardized reversible (patho)physiologically relevant interventions, such as brief periods of aortic occlusion, hypoxia, and hyperoxia, are used for detailing the relation between the MR-PHYSIOL parameters, in particular between renal T 2* and tissue oxygenation.
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Acknowledgements
This work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, research unit: FOR 1368, grant numbers: NI 532/9-1, NI 532/9-2, SE 998/4-2). The authors wish to thank Ariane Anger, Bert Flemming, Andrea Gerhardt, Jan Hentschel, Uwe Hoff, Mechthild Ladwig, and Sonia Waiczies for their help and support with developing the described methods.
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Cantow, K., Arakelyan, K., Seeliger, E., Niendorf, T., Pohlmann, A. (2016). Assessment of Renal Hemodynamics and Oxygenation by Simultaneous Magnetic Resonance Imaging (MRI) and Quantitative Invasive Physiological Measurements. In: Hewitson, T., Smith, E., Holt, S. (eds) Kidney Research. Methods in Molecular Biology, vol 1397. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3353-2_11
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DOI: https://doi.org/10.1007/978-1-4939-3353-2_11
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