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Assessment of Renal Hemodynamics and Oxygenation by Simultaneous Magnetic Resonance Imaging (MRI) and Quantitative Invasive Physiological Measurements

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Kidney Research

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1397))

Abstract

In vivo assessment of renal perfusion and oxygenation under (patho)physiological conditions by means of noninvasive diagnostic imaging is conceptually appealing. Blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) and quantitative parametric mapping of the magnetic resonance (MR) relaxation times T 2* and T 2 are thought to provide surrogates of renal tissue oxygenation. The validity and efficacy of this technique for quantitative characterization of local tissue oxygenation and its changes under different functional conditions have not been systematically examined yet and remain to be established. For this purpose, the development of an integrative multimodality approaches is essential. Here we describe an integrated hybrid approach (MR-PHYSIOL) that combines established quantitative physiological measurements with T 2* (T 2) mapping and MR-based kidney size measurements. Standardized reversible (patho)physiologically relevant interventions, such as brief periods of aortic occlusion, hypoxia, and hyperoxia, are used for detailing the relation between the MR-PHYSIOL parameters, in particular between renal T 2* and tissue oxygenation.

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Acknowledgements

This work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, research unit: FOR 1368, grant numbers: NI 532/9-1, NI 532/9-2, SE 998/4-2). The authors wish to thank Ariane Anger, Bert Flemming, Andrea Gerhardt, Jan Hentschel, Uwe Hoff, Mechthild Ladwig, and Sonia Waiczies for their help and support with developing the described methods.

Author information

Authors and Affiliations

  1. Institute of Physiology, Charité—Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany

    Kathleen Cantow, Karen Arakelyan & Erdmann Seeliger

  2. Center for Cardiovascular Research, Berlin, Germany

    Kathleen Cantow, Karen Arakelyan & Erdmann Seeliger

  3. Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany

    Thoralf Niendorf & Andreas Pohlmann

Authors
  1. Kathleen Cantow
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  2. Karen Arakelyan
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  3. Erdmann Seeliger
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  4. Thoralf Niendorf
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  5. Andreas Pohlmann
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Corresponding author

Correspondence to Andreas Pohlmann .

Editor information

Editors and Affiliations

  1. Royal Hospital Melbourne Dept. Nephrology, Melbourne, Victoria, Australia

    Tim D. Hewitson

  2. Department of Nephrology, Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia

    Edward R. Smith

  3. Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia

    Stephen G. Holt

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© 2016 Springer Science+Business Media New York

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Cantow, K., Arakelyan, K., Seeliger, E., Niendorf, T., Pohlmann, A. (2016). Assessment of Renal Hemodynamics and Oxygenation by Simultaneous Magnetic Resonance Imaging (MRI) and Quantitative Invasive Physiological Measurements. In: Hewitson, T., Smith, E., Holt, S. (eds) Kidney Research. Methods in Molecular Biology, vol 1397. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3353-2_11

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  • DOI: https://doi.org/10.1007/978-1-4939-3353-2_11

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3351-8

  • Online ISBN: 978-1-4939-3353-2

  • eBook Packages: Springer Protocols

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