Abstract
Hematopoietic stem cell transplantation (HSCT) from an allogeneic donor is an effective form of cancer immunotherapy, especially for acute leukemias. HSCT is however frequently complicated by the occurrence of graft-versus-host disease (GVHD). Immunocompromised mice infused with human T cells often develop a clinical syndrome resembling human GVHD (xenogeneic or X-GVHD). Herein, we describe a method for inducing X-GVHD in a highly reproducible manner. Given the human nature of immune effectors, this xenogeneic model can be routinely adopted for screening the efficacy of new treatments for GVHD.
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Norelli, M., Camisa, B., Bondanza, A. (2016). Modeling Human Graft-Versus-Host Disease in Immunocompromised Mice. In: Bondanza, A., Casucci, M. (eds) Tumor Immunology. Methods in Molecular Biology, vol 1393. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3338-9_12
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DOI: https://doi.org/10.1007/978-1-4939-3338-9_12
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Publisher Name: Humana Press, New York, NY
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Online ISBN: 978-1-4939-3338-9
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