Isolation of Synaptic Current

  • Nicholas GrazianeEmail author
  • Yan Dong
Part of the Neuromethods book series (NM, volume 112)


Synaptic currents can be examined by a variety of different approaches such as isolating quantal currents or evoking currents using electrical or optical stimulation. It is important for a beginning electrophysiologist to fully comprehend each approach so that the right method is used for the intended scientific question. Below we provide conceptual and technical information for miniature, spontaneous, quantal, and evoked postsynaptic currents with useful references that provide additional and in some cases more detailed information.

Key words

Miniature postsynaptic currents Spontaneous postsynaptic currents Quantal postsynaptic currents Evoked currents Optical stimulation Electrical stimulation DREADDs Nanoparticles 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Neuroscience DepartmentUniversity of PittsburghPittsburghUSA

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