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Electrophysiological Analysis of Synaptic Transmission pp 145–156Cite as

Long-Term Measurements

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Part of the book series: Neuromethods ((NM,volume 112))

Abstract

Long-term measurements in slice electrophysiology typically constitute long-term potentiation (LTP) and long-term depression (LTD). These measurements can last 1–2 h, requiring minimal baseline noise and easy detection of activated synaptic receptors. This can be relatively easy to achieve in field recordings, but can be challenging in whole-cell configurations. In this chapter, we discuss the concepts behind LTP and LTD as well as the approaches that the beginning electrophysiologist can use in order to complete these long-term measurements. We finish with potential technical issues to consider during experimentation as well as suggestions that may increase the likelihood of successful recordings.

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Authors and Affiliations

  1. Neuroscience Department, University of Pittsburgh, Langley Hall, Pittsburgh, PA, 15260, USA

    Nicholas Graziane & Yan Dong

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  1. Nicholas Graziane
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  2. Yan Dong
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Correspondence to Nicholas Graziane .

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Graziane, N., Dong, Y. (2016). Long-Term Measurements. In: Electrophysiological Analysis of Synaptic Transmission. Neuromethods, vol 112. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3274-0_12

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  • DOI: https://doi.org/10.1007/978-1-4939-3274-0_12

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3273-3

  • Online ISBN: 978-1-4939-3274-0

  • eBook Packages: Springer Protocols

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