Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS
Buprenorphine (Suboxone, Zubsolv, Buprenex, Butrans, etc.) is an opioid drug that has been used to treat opioid dependence on an outpatient basis, and is also prescribed for managing moderate to severe pain. Pregnant women may be prescribed buprenorphine as part of a treatment plan for opioid addiction. This chapter quantitates buprenorphine and norbuprenorphine in meconium by liquid chromatography tandem mass spectrometry (LC-MS/MS).
Key wordsBuprenorphine LC-MS/MS Meconium Neonate Neonatal abstinence syndrome NAS Pregnancy