Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS

  • Stephanie J. MarinEmail author
  • Gwendolyn A. McMillin
Part of the Methods in Molecular Biology book series (MIMB, volume 1383)


Buprenorphine (Suboxone, Zubsolv, Buprenex, Butrans, etc.) is an opioid drug that has been used to treat opioid dependence on an outpatient basis, and is also prescribed for managing moderate to severe pain. Pregnant women may be prescribed buprenorphine as part of a treatment plan for opioid addiction. This chapter quantitates buprenorphine and norbuprenorphine in meconium by liquid chromatography tandem mass spectrometry (LC-MS/MS).

Key words

Buprenorphine LC-MS/MS Meconium Neonate Neonatal abstinence syndrome NAS Pregnancy 


  1. 1.
    Jones HE (2010) Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med 363(24):2320–2331PubMedCentralCrossRefPubMedGoogle Scholar
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    Kacinko SL et al (2008) Correlations of Maternal Buprenorphine Dose, Buprenorphine, and Metabolite Concentrations in Meconium with Neonatal Outcomes. Clin Pharmacol Ther 84(5):604–612PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.ARUP Institute for Clinical and Experimental PathologySalt Lake CityUSA
  2. 2.ARUP LaboratoriesSalt Lake CityUSA
  3. 3.Department of PathologyUniversity of Utah School of MedicineSalt Lake CityUSA

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