Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology

  • Uttam GargEmail author
  • Yan Victoria Zhang
Part of the Methods in Molecular Biology book series (MIMB, volume 1383)


Mass spectrometry (MS) has been used in research and specialized clinical laboratories for decades as a very powerful technology to identify and quantify compounds. In recent years, application of MS in routine clinical laboratories has increased significantly. This is mainly due to the ability of MS to provide very specific identification, high sensitivity, and simultaneous analysis of multiple analytes (>100). The coupling of tandem mass spectrometry with gas chromatography (GC) or liquid chromatography (LC) has enabled the rapid expansion of this technology. While applications of MS are used in many clinical areas, therapeutic drug monitoring, drugs of abuse, and clinical toxicology are still the primary focuses of the field. It is not uncommon to see mass spectrometry being used in routine clinical practices for those applications.

Key words

Clinical laboratory Mass spectrometry Liquid chromatography Gas chromatography Tandem mass spectrometry Drugs Therapeutic drug monitoring Toxicology Time-of-flight Immunoassays 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineChildren’s Mercy Hospitals and ClinicsKansas CityUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of RochesterRochesterUSA

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