Abstract
The behavioral phenotypes of mice are the result of a complex interplay between overall health, sensory abilities, learning and memory, motor function as well as developmental milestones, feeding, sexual, parental, and social behaviors. This chapter lists a selected number of key behavioral tests, specifically designed to assay fundamental behavioral features such as memory, activity, and motor skills in mice models.
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References
De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L et al (2003) Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 33(2):192–196
de Carvalho AP, Sweadner KJ, Penniston JT, Zaremba J, Liu L, Caton M et al (2004) Mutations in the Na+/K+-ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism. Neuron 43(2):169–175
Heinzen EL, Swoboda KJ, Hitomi Y, Gurrieri F, Nicole S, de Vries B et al (2012) De novo mutations in ATP1A3 cause alternating hemiplegia of childhood. Nat Genet 44(9):1030–1034
Rosewich H, Thiele H, Ohlenbusch A, Maschke U, Altmuller J, Frommolt P et al (2012) Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study. Lancet Neurol 11(9):764–773
Demos MK, van Karnebeek CD, Ross CJ, Adam S, Shen Y, Zhan SH et al (2014) A novel recurrent mutation in ATP1A3 causes CAPOS syndrome. Orphanet J Rare Dis 9:15
Heinzen EL, Arzimanoglou A, Brashear A, Clapcote SJ, Gurrieri F, Goldstein DB et al (2014) Distinct neurological disorders with ATP1A3 mutations. Lancet Neurol 13(5):503–514
Bottger P, Doganli C, Lykke-Hartmann K (2012) Migraine- and dystonia-related disease-mutations of Na+/K+-ATPases: relevance of behavioral studies in mice to disease symptoms and neurological manifestations in humans. Neurosci Biobehav Rev 36(2):855–871
Picciotto MR, Wickman K (1998) Using knockout and transgenic mice to study neurophysiology and behavior. Physiol Rev 78(4):1131–1163
Walsh RN, Cummins RA (1976) The Open-Field Test: a critical review. Psychol Bull 83(3):482–504
Gould TD, Dao DT, Kovacsics CE. The open field test. Springer Protocols. 2009;42(Mood and Anxiety Related Phenotypes in Mice. Neuromethods). 1–20
Gould T, Dao T, Kovacsics C (2009) The open field test. Mood and anxiety related phenotypes in mice. Humana, New York, pp 1–20
McGaugh JL (1966) Time-dependent processes in memory storage. Science 153(3742):1351–1358
Barnes CA (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 93(1):74–104
Sunyer B, Patil S, Höger H, Lubec G (2007) Barnes maze, a useful task to assess spatial reference memory in the mice. Nat Protoc (Protocol Exchange)
Mayford M, Bach ME, Huang YY, Wang L, Hawkins RD, Kandel ER (1996) Control of memory formation through regulated expression of a CaMKII transgene. Science 274(5293):1678–1683
Carter RJ, Morton J, Dunnett SB (2001) Motor coordination and balance in rodents. In: Jacqueline N. Crawley et al. Current protocols in neuroscience. Chapter 8:Unit 8 12
Cabe PA, Tilson HA, Mitchell CL, Dennis R (1978) A simple recording grip strength device. Pharmacol Biochem Behav 8(1):101–102
Lambertsen KL, Gramsbergen JB, Sivasaravanaparan M, Ditzel N, Sevelsted-Moller LM, Olivan-Viguera A et al (2012) Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels. PLoS One 7(10), e47744
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Isaksen, T.J., Holm, T.H., Lykke-Hartmann, K. (2016). Behavior Test Relevant to α2/α3Na+/K+-ATPase Gene Modified Mouse Models. In: Bublitz, M. (eds) P-Type ATPases. Methods in Molecular Biology, vol 1377. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3179-8_30
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DOI: https://doi.org/10.1007/978-1-4939-3179-8_30
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-3178-1
Online ISBN: 978-1-4939-3179-8
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