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Biocompatibility of Nanomaterials

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Nanomaterials in Pharmacology

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Remarkable progress has been made in the field of nanotechnology in the past decade. Many new nanoparticles, which are defined as particles with at least one dimension between 1 and 100 nm, have been created, and new medical applications for these nanoparticles are now expected. To be able to create effective and safe nanomedicines, more information is needed about the effects and safety of nanoparticles in vivo because physical properties such as material composition, particle size, surface area, surface chemistry, surface charge, and agglomeration state all influence nanoparticle biocompatibility, particularly with regard to activation of the complement, coagulation, and immune systems. In this chapter, we introduce the most recent developments in our understanding of the biocompatibility of nanoparticles and discuss how our current understanding translates to the field of nanomedicine.

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Authors and Affiliations

  1. Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Yasuo Yoshioka Ph.D., Kazuma Higashisaka & Yasuo Tsutsumi Ph.D.

  2. Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, 7-6-8 Saitoasagi, Ibaraki, Osaka, 567-0085, Japan

    Yasuo Yoshioka Ph.D., Kazuma Higashisaka & Yasuo Tsutsumi Ph.D.

  3. The Center for Advanced Medical Engineering and Informatics, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Yasuo Tsutsumi Ph.D.

Authors
  1. Yasuo Yoshioka Ph.D.
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  2. Kazuma Higashisaka
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  3. Yasuo Tsutsumi Ph.D.
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Correspondence to Yasuo Tsutsumi Ph.D. .

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Editors and Affiliations

  1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA

    Zheng-Rong Lu

  2. Laboratory of Drug Delivery System, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan

    Shinji Sakuma

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Yoshioka, Y., Higashisaka, K., Tsutsumi, Y. (2016). Biocompatibility of Nanomaterials. In: Lu, ZR., Sakuma, S. (eds) Nanomaterials in Pharmacology. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3121-7_9

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  • DOI: https://doi.org/10.1007/978-1-4939-3121-7_9

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